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Research Articles, Systems/Circuits

Emergence of Distinct Neural Subspaces in Motor Cortical Dynamics during Volitional Adjustments of Ongoing Locomotion

David Xing, Wilson Truccolo and David A. Borton
Journal of Neuroscience 7 December 2022, 42 (49) 9142-9157; DOI: https://doi.org/10.1523/JNEUROSCI.0746-22.2022
David Xing
1School of Engineering, Brown University, Providence, Rhode Island 02912
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Wilson Truccolo
2Department of Neuroscience, Brown University, Providence, Rhode Island 02912
3Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912
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David A. Borton
1School of Engineering, Brown University, Providence, Rhode Island 02912
3Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912
4Center for Neurorestoration & Neurotechnology, Rehabilitation Research and Development Service, Department of Veterans Affairs, Providence, Rhode Island 02908
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0746-22.2022
PubMed 
36283830
Published By 
Society for Neuroscience
History 
  • Received March 27, 2022
  • Revision received October 10, 2022
  • Accepted October 12, 2022
  • First published October 25, 2022.
  • Version of record published December 7, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. David Xing1,
  2. Wilson Truccolo2,3, and
  3. David A. Borton1,3,4
  1. 1School of Engineering, Brown University, Providence, Rhode Island 02912
  2. 2Department of Neuroscience, Brown University, Providence, Rhode Island 02912
  3. 3Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912
  4. 4Center for Neurorestoration & Neurotechnology, Rehabilitation Research and Development Service, Department of Veterans Affairs, Providence, Rhode Island 02908
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Author contributions

  1. Author contributions: D.X., W.T., and D.A.B. designed research; D.X. performed research; D.A.B. contributed unpublished reagents/analytic tools; D.X., W.T., and D.A.B. analyzed data; D.X. wrote the paper.

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Disclosures

    • Received March 27, 2022.
    • Revision received October 10, 2022.
    • Accepted October 12, 2022.
  • This work was sponsored in part by the Defense Advanced Research Projects Agency (DARPA) BTO under the auspices of Dr. Doug Weber and Alfred Emondi through the Space and Naval Warfare Systems Center Pacific or DARPA Contracts Management Office, Grant/Contract No. D15AP00112 (to D.A.B.); and by Merit Review Award #I01RX002835 from the US Department of Veterans Affairs, Rehabilitation Research and Development Service (to D.A.B.). The contents of this manuscript do not represent the views of the Veterans Administration or the United States Government. The Department of Veterans Affairs did not provide any direct support for the animal work conducted for this project. We thank Ellen Xing for contributing to the creation of Figure 1 and Figure 2. We also thank the Pablo J. Salame Goldman Sachs endowed Associate Professorship of Computational Neuroscience at Brown University (to W.T.); and the Howard Reisman '76 Family Graduate Fellowship Fund, and the Charles A. Dana Graduate Fellowship Fund (to D.X.). These funding sources had no involvement in the design of this study, the collection or analysis of data, or the authorship of this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to David A. Borton at david_borton{at}brown.edu

Funding

  • DOD | Defense Advanced Research Projects Agency (DARPA)

    D15AP00112
  • U.S. Department of Veterans Affairs (VA)

    I01RX002835

Other Version

  • previous version (October 25, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (49)
Journal of Neuroscience
Vol. 42, Issue 49
7 Dec 2022
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Emergence of Distinct Neural Subspaces in Motor Cortical Dynamics during Volitional Adjustments of Ongoing Locomotion
David Xing, Wilson Truccolo, David A. Borton
Journal of Neuroscience 7 December 2022, 42 (49) 9142-9157; DOI: 10.1523/JNEUROSCI.0746-22.2022

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Emergence of Distinct Neural Subspaces in Motor Cortical Dynamics during Volitional Adjustments of Ongoing Locomotion
David Xing, Wilson Truccolo, David A. Borton
Journal of Neuroscience 7 December 2022, 42 (49) 9142-9157; DOI: 10.1523/JNEUROSCI.0746-22.2022
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Keywords

  • cortical dynamics
  • locomotion
  • motor control
  • neural subspaces

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