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Featured ArticleResearch Articles, Systems/Circuits

Nociceptive Stimuli Activate the Hypothalamus–Habenula Circuit to Inhibit the Mesolimbic Reward System and Cocaine-Seeking Behaviors

Soo Min Lee, Han Byeol Jang, Yu Fan, Bong Hyo Lee, Sang Chan Kim, Kyle B. Bills, Scott C. Steffensen and Hee Young Kim
Journal of Neuroscience 7 December 2022, 42 (49) 9180-9192; DOI: https://doi.org/10.1523/JNEUROSCI.0577-22.2022
Soo Min Lee
1Emotion, Cognition & Behavior Research Group, Korea Brain Research Institute, Daegu 41062, South Korea
3Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, South Korea
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Han Byeol Jang
3Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, South Korea
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Yu Fan
2Department of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China
3Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, South Korea
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Bong Hyo Lee
3Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, South Korea
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Sang Chan Kim
4Medical Research Center, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, South Korea
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Kyle B. Bills
5Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, Utah 84606
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Scott C. Steffensen
6Department of Psychology and Neuroscience, Brigham Young University, Provo, Utah 84602
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Hee Young Kim
7Department of Physiology, Yonsei University College of Medicine, Seoul 03722, South Korea
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0577-22.2022
PubMed 
36280259
Published By 
Society for Neuroscience
History 
  • Received March 23, 2022
  • Revision received October 6, 2022
  • Accepted October 11, 2022
  • First published October 24, 2022.
  • Version of record published December 7, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Soo Min Lee1,3,*,
  2. Han Byeol Jang3,*,
  3. Yu Fan2,3,*,
  4. Bong Hyo Lee3,
  5. Sang Chan Kim4,
  6. Kyle B. Bills5,
  7. Scott C. Steffensen6, and
  8. Hee Young Kim7
  1. 1Emotion, Cognition & Behavior Research Group, Korea Brain Research Institute, Daegu 41062, South Korea
  2. 2Department of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China
  3. 3Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, South Korea
  4. 4Medical Research Center, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, South Korea
  5. 5Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, Utah 84606
  6. 6Department of Psychology and Neuroscience, Brigham Young University, Provo, Utah 84602
  7. 7Department of Physiology, Yonsei University College of Medicine, Seoul 03722, South Korea
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Author contributions

  1. Author contributions: H.-Y.K. designed research; H.-Y.K., B.-H.L., S.-M.L., Y.F., and H.-B.J. performed research; B.-H.L., S.-C.K., K.B.B., and S.C.S. contributed unpublished reagents/analytic tools; S.-M.L. and Y.F. analyzed data; S.-M.L., S.C.S. and H.-Y.K. wrote the paper.

  2. ↵*S.-M.L., H.-B.J. and Y.F. contributed equally to this work.

View Full Text

Disclosures

    • Received March 23, 2022.
    • Revision received October 6, 2022.
    • Accepted October 11, 2022.
  • This work was supported by National Research Foundation of Korea Grants 2018R1A5A2025272, 2019R1A2C1002555, and 2022K2A9A2A0601867911; Korea Institute of Oriental Medicine Grants KSN1812181; and Ministry of Agriculture, Food, and Rural Affairs Grant 322096-051SB010.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Hee Young Kim at vet202001{at}yuhs.ac

Funding

  • National Research Foundation of Korea (NRF)

    2018R1A5A2025272; 2019R1A2C1002555; 2019R1A6A3A13090969
  • Korea Institute of Oriental Medicine (KIOM)

    KSN1812181; KSN2013210
  • Ministry of Agriculture, Food and Rural Affairs(MAFRA)

    322096-5

Other Version

  • previous version (October 24, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (49)
Journal of Neuroscience
Vol. 42, Issue 49
7 Dec 2022
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Nociceptive Stimuli Activate the Hypothalamus–Habenula Circuit to Inhibit the Mesolimbic Reward System and Cocaine-Seeking Behaviors
Soo Min Lee, Han Byeol Jang, Yu Fan, Bong Hyo Lee, Sang Chan Kim, Kyle B. Bills, Scott C. Steffensen, Hee Young Kim
Journal of Neuroscience 7 December 2022, 42 (49) 9180-9192; DOI: 10.1523/JNEUROSCI.0577-22.2022

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Nociceptive Stimuli Activate the Hypothalamus–Habenula Circuit to Inhibit the Mesolimbic Reward System and Cocaine-Seeking Behaviors
Soo Min Lee, Han Byeol Jang, Yu Fan, Bong Hyo Lee, Sang Chan Kim, Kyle B. Bills, Scott C. Steffensen, Hee Young Kim
Journal of Neuroscience 7 December 2022, 42 (49) 9180-9192; DOI: 10.1523/JNEUROSCI.0577-22.2022
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Keywords

  • cocaine addiction
  • dopamine
  • lateral habenula
  • lateral hypothalamus
  • nociception

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