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Featured ArticleResearch Articles, Neurobiology of Disease

Presenilin and APP Regulate Synaptic Kainate Receptors

Gaël Barthet, Ana Moreira-de-Sá, Pei Zhang, Séverine Deforges, Jorge Castanheira, Adam Gorlewicz and Christophe Mulle
Journal of Neuroscience 7 December 2022, 42 (49) 9253-9262; https://doi.org/10.1523/JNEUROSCI.0297-22.2022
Gaël Barthet
Université of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience (IINS), UMR 5297, F-33000 Bordeaux, France
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Ana Moreira-de-Sá
Université of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience (IINS), UMR 5297, F-33000 Bordeaux, France
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Pei Zhang
Université of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience (IINS), UMR 5297, F-33000 Bordeaux, France
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Séverine Deforges
Université of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience (IINS), UMR 5297, F-33000 Bordeaux, France
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Jorge Castanheira
Université of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience (IINS), UMR 5297, F-33000 Bordeaux, France
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Adam Gorlewicz
Université of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience (IINS), UMR 5297, F-33000 Bordeaux, France
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Christophe Mulle
Université of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience (IINS), UMR 5297, F-33000 Bordeaux, France
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0297-22.2022
PubMed 
36288945
Published By 
Society for Neuroscience
History 
  • Received February 10, 2022
  • Revision received August 25, 2022
  • Accepted September 27, 2022
  • First published October 26, 2022.
  • Version of record published December 7, 2022.
Copyright & Usage 
Copyright © 2022 the authors SfN exclusive license.

Author Information

  1. Gaël Barthet*,
  2. Ana Moreira-de-Sá*,
  3. Pei Zhang,
  4. Séverine Deforges,
  5. Jorge Castanheira,
  6. Adam Gorlewicz, and
  7. Christophe Mulle
  1. Université of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience (IINS), UMR 5297, F-33000 Bordeaux, France
View Full Text

Author contributions

  1. Author contributions: G.B. and C.M. designed research; G.B., A.M.-d.-S., P.Z., S.D., J.C., and A.G. performed research; G.B., A.M.-d.-S., and P.Z. analyzed data; C.M. wrote the paper.

  2. ↵*G.B. and A.M.-d.-S. contributed equally to this work.

Disclosures

    • Received February 10, 2022.
    • Revision received August 25, 2022.
    • Accepted September 27, 2022.
  • This work was supported by the Centre National de la Recherche Scientifique (CNRS); a French ANR (Agence Nationale de la Recherche) PREPLASH Project grant; a grant from the Fondation France Alzheimer; and the Erasmus Mundus program “European Neuroscience Campus” from the Seventh Framework Programme (to P.Z.). We thank Justine Gautron for her help with some biochemistry experiments. We also thank the Bordeaux Imaging Center (BIC), a service unit of the CNRS-Institut National de la Santé et de la Recherche Médicale and Bordeaux University, which is a member of the national infrastructure France BioImaging, for help in performing microscopy.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Christophe Mulle at christophe.mulle{at}u-bordeaux.fr

Funding

  • Centre National de la Recherche Scientifique (CNRS)

  • Agence Nationale de la Recherche (ANR)

  • Fondation pour la Recherche Médicale (FRM)

Other Version

  • previous version (October 26, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 42 (49)
Journal of Neuroscience
Vol. 42, Issue 49
7 Dec 2022
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Presenilin and APP Regulate Synaptic Kainate Receptors
Gaël Barthet, Ana Moreira-de-Sá, Pei Zhang, Séverine Deforges, Jorge Castanheira, Adam Gorlewicz, Christophe Mulle
Journal of Neuroscience 7 December 2022, 42 (49) 9253-9262; DOI: 10.1523/JNEUROSCI.0297-22.2022

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Presenilin and APP Regulate Synaptic Kainate Receptors
Gaël Barthet, Ana Moreira-de-Sá, Pei Zhang, Séverine Deforges, Jorge Castanheira, Adam Gorlewicz, Christophe Mulle
Journal of Neuroscience 7 December 2022, 42 (49) 9253-9262; DOI: 10.1523/JNEUROSCI.0297-22.2022
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Keywords

  • Alzheimer's disease
  • APP
  • kainate receptors
  • presenilin
  • synapse

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