Involvement of Denervated Midbrain-Derived Factors in the Formation of Ectopic Cortico-Mesencephalic Projection after Hemispherectomy

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¹Laboratory of Cellular and Molecular Neurobiology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan
²Department of Applied Bioscience, Kanazawa Institute of Technology (KIT), Hakusan, Ishikawa 924-0838, Japan
³Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577, Japan

Author contributions: L.C. and N.Y. designed research; L.C. and M.M. performed research; M.K. contributed unpublished reagents/analytic tools; N.Y. edited the paper; L.C. and M.M. analyzed data; L.C. wrote the first draft of the paper; L.C. and N.Y. wrote the paper.

This work was supported by Grants-in-Aid for Scientific Research on “Dynamic regulation of brain function by Scrap & Build system” (No. 16H06460) and “Mechanisms underlying the functional shift of brain neural circuitry for behavioral adaptation” (No. 17H05569) from the Japanese Ministry of Education, Culture, Sports, Science and Technology and by Grants-in-Aid for Scientific Research 19H03325 (to N.Y.) and 20J13844 (to L.C.) from the Japan Society for the Promotion of Science. We dedicate this paper to the late Professor Nakaakira Tsukahara and Mrs. Masako Tsukahara. We thank Dr. Ian Smith and Dr. Fujio Murakami for critical reading of the manuscript. We thank the Otsuka Toshimi Scholarship Foundation and the Rotary Yoneyama Memorial Foundation for scholarship support to L.C.
The authors declare no competing financial interests.
Correspondence should be addressed to Nobuhiko Yamamoto at nobuhiko{at}fbs.osaka-u.ac.jp

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