Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines

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¹Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
²Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121

Author contributions: R.D.H., B.B.-D., M.G.S., and C.L.C. performed research; R.D.H., B.B.-D., and S.D.R. analyzed data; B.B.-D. and S.D.R. edited the paper; S.D.R. designed research; S.D.R. wrote the paper.
↵*R.D.H. and B.B.-D. contributed equally to this work.

This work was supported in part by Canadian Institutes of Health Research 2014-685 to S.D.R.; Natural Sciences and Engineering Research Council of Canada RG060805 and CRDPJ 490841-15 to S.D.R., CGSM to R.D.H., and PSSO and OGS to B.B.-D.; and Vanier Program to M.G.S. We thank Tinya Wang for technical assistance with DAF-FM; and Stuart Lipton for critical editing of this manuscript.
The authors declare no competing financial interests.
Correspondence should be addressed to Scott D. Ryan at sryan03{at}uoguelph.ca

Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)
2014-685
Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)
RG060805 and CRDPJ: 490841-15