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The Importance of Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes

Edward Zagha, Jeffrey C. Erlich, Soohyun Lee, Gyorgy Lur, Daniel H. O'Connor, Nicholas A. Steinmetz, Carsen Stringer and Hongdian Yang
Journal of Neuroscience 23 February 2022, 42 (8) 1375-1382; DOI: https://doi.org/10.1523/JNEUROSCI.1919-21.2021
Edward Zagha
1Department of Psychology, Neuroscience Graduate Program, University of California Riverside, Riverside, California 92521
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Jeffrey C. Erlich
2NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, 200062, China; NYU Shanghai, Shanghai, 200122, China; and Shanghai Key Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, Shanghai, 200062, China
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Soohyun Lee
3Unit on Functional Neural Circuits, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892
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Gyorgy Lur
4Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697
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Daniel H. O'Connor
5Solomon H. Snyder Department of Neuroscience & Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218
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Nicholas A. Steinmetz
6Department of Biological Structure, University of Washington, Seattle, Washington 98195
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Carsen Stringer
7HHMI Janelia Research Campus, Ashburn, Virginia 20147
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Hongdian Yang
8Department of Molecular, Cell and Systems Biology, Neuroscience Graduate Program, University of California, Riverside, California 92521
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Abstract

A surprising finding of recent studies in mouse is the dominance of widespread movement-related activity throughout the brain, including in early sensory areas. In awake subjects, failing to account for movement risks misattributing movement-related activity to other (e.g., sensory or cognitive) processes. In this article, we (1) review task designs for separating task-related and movement-related activity, (2) review three “case studies” in which not considering movement would have resulted in critically different interpretations of neuronal function, and (3) discuss functional couplings that may prevent us from ever fully isolating sensory, motor, and cognitive-related activity. Our main thesis is that neural signals related to movement are ubiquitous, and therefore ought to be considered first and foremost when attempting to correlate neuronal activity with task-related processes.

  • behavior
  • cognition
  • movement
  • neural coding
  • sensorimotor
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The Journal of Neuroscience: 42 (8)
Journal of Neuroscience
Vol. 42, Issue 8
23 Feb 2022
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The Importance of Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes
Edward Zagha, Jeffrey C. Erlich, Soohyun Lee, Gyorgy Lur, Daniel H. O'Connor, Nicholas A. Steinmetz, Carsen Stringer, Hongdian Yang
Journal of Neuroscience 23 February 2022, 42 (8) 1375-1382; DOI: 10.1523/JNEUROSCI.1919-21.2021

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The Importance of Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes
Edward Zagha, Jeffrey C. Erlich, Soohyun Lee, Gyorgy Lur, Daniel H. O'Connor, Nicholas A. Steinmetz, Carsen Stringer, Hongdian Yang
Journal of Neuroscience 23 February 2022, 42 (8) 1375-1382; DOI: 10.1523/JNEUROSCI.1919-21.2021
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Keywords

  • behavior
  • cognition
  • movement
  • neural coding
  • sensorimotor

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