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Research Articles, Systems/Circuits

Preferential Modulatory Action of 5-HT2A Receptors on the Dynamic Regulation of Basal Ganglia Circuits

Lise Guilhemsang, Amaia Gutierrez-Ceballos, Mario Antonazzo, Nicolas P. Mallet, Luisa Ugedo and Teresa Morera-Herreras
Journal of Neuroscience 4 January 2023, 43 (1) 56-67; DOI: https://doi.org/10.1523/JNEUROSCI.1181-22.2022
Lise Guilhemsang
1Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain
2Université de Bordeaux, Institut des Maladies Neurodégénératives, 33076 Bordeaux, France
3Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université de Bordeaux 33076 Bordeaux, France
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Amaia Gutierrez-Ceballos
1Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain
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Mario Antonazzo
1Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain
4Neurodegenerative Diseases Group, Biocruces Health Research Institute, 48903 Barakaldo, Spain
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Nicolas P. Mallet
2Université de Bordeaux, Institut des Maladies Neurodégénératives, 33076 Bordeaux, France
3Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université de Bordeaux 33076 Bordeaux, France
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Luisa Ugedo
1Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain
4Neurodegenerative Diseases Group, Biocruces Health Research Institute, 48903 Barakaldo, Spain
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Teresa Morera-Herreras
1Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain
4Neurodegenerative Diseases Group, Biocruces Health Research Institute, 48903 Barakaldo, Spain
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1181-22.2022
PubMed 
36400530
Published By 
Society for Neuroscience
History 
  • Received June 15, 2022
  • Revision received October 24, 2022
  • Accepted October 30, 2022
  • First published November 18, 2022.
  • Version of record published January 4, 2023.
Copyright & Usage 
Copyright © 2023 the authors SfN exclusive license.

Author Information

  1. Lise Guilhemsang1,2,3,
  2. Amaia Gutierrez-Ceballos1,
  3. Mario Antonazzo1,4,
  4. Nicolas P. Mallet2,3,
  5. Luisa Ugedo1,4, and
  6. Teresa Morera-Herreras1,4
  1. 1Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain
  2. 2Université de Bordeaux, Institut des Maladies Neurodégénératives, 33076 Bordeaux, France
  3. 3Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université de Bordeaux 33076 Bordeaux, France
  4. 4Neurodegenerative Diseases Group, Biocruces Health Research Institute, 48903 Barakaldo, Spain
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Author contributions

  1. Author contributions: L.U. and T.M.-H. designed research; L.G., A.G.-C., M.A., and N.P.M. performed research; L.G., A.G.-C., M.A., and T.M.-H. analyzed data; L.U. and T.M.-H. wrote the paper.

View Full Text

Disclosures

    • Received June 15, 2022.
    • Revision received October 24, 2022.
    • Accepted October 30, 2022.
  • This study was supported by the University of the Basque Country (Grant GIU19/092), the Basque Government (Grant IT1706-22), and the Ministry of Economy and Competitiveness of Spain (Grant SAF2016-77758-R, Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional, European Union). This research was conducted in the scope of the Transborder Joint Laboratory (LTC) “non-motor comorbidities in Parkinson's disease (CoMorPD).” L.G. has a fellowship from the University of the Basque Country. M.A. had a fellowship from the MECD. We thank Raphaelle Bidgood for language editing assistance and comments on the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Teresa Morera-Herreras at teresa.morera{at}ehu.eus

Funding

  • Euskal Herriko Unibertsitatea (EHU)

    GIU19/092
  • Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España (MINECO)

    SAF2016-77758-R
  • Basque Government

    IT1706-22

Other Version

  • previous version (November 18, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 43 (1)
Journal of Neuroscience
Vol. 43, Issue 1
4 Jan 2023
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Preferential Modulatory Action of 5-HT2A Receptors on the Dynamic Regulation of Basal Ganglia Circuits
Lise Guilhemsang, Amaia Gutierrez-Ceballos, Mario Antonazzo, Nicolas P. Mallet, Luisa Ugedo, Teresa Morera-Herreras
Journal of Neuroscience 4 January 2023, 43 (1) 56-67; DOI: 10.1523/JNEUROSCI.1181-22.2022

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Preferential Modulatory Action of 5-HT2A Receptors on the Dynamic Regulation of Basal Ganglia Circuits
Lise Guilhemsang, Amaia Gutierrez-Ceballos, Mario Antonazzo, Nicolas P. Mallet, Luisa Ugedo, Teresa Morera-Herreras
Journal of Neuroscience 4 January 2023, 43 (1) 56-67; DOI: 10.1523/JNEUROSCI.1181-22.2022
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Keywords

  • 5-HT2A receptor
  • basal ganglia circuits
  • fluoxetine
  • pCPA
  • serotonin
  • TCB-2

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