Effect of Selective Lesions of Nucleus Accumbens µ-Opioid Receptor-Expressing Cells on Heroin Self-Administration in Male and Female Rats: A Study with Novel Oprm1-Cre Knock-in Rats

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¹Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
²University of Michigan, Ann Arbor, Michigan, 48104
³University of Strasbourg–Institut National de la Santé et de la Recherche Médicale U1114, Strasbourg, France, 67084

C.A. Mejias-Aponte's present address: Intramural Research Program, National Eye Institute-National Institutes of Health, Bethesda, Maryland.

Author contributions: J.M.B., C.A.M.-A., T.S., V.K., A.S., B.K.H., C.T.R., J.L.G., M.M., B.L.K., S.J.W., H.A., and Y.S. designed research; J.M.B., C.A.M.-A., T.S., L.A., M.E., I.F., A.B., S.M.C., K.E.C., D.J.R., M.F., V.K., E.H., W.F., C.T.R., J.L.G., and M.M. performed research; J.M.B., C.A.M.-A., L.A., M.E., A.B., K.E.C., J.J.C., M.F., V.K., E.H., W.F., J.L.G., M.M., and Y.S. analyzed data; J.M.B. and Y.S. wrote the first draft of the paper; J.M.B., C.A.M.-A., T.S., M.E., I.F., A.B., S.M.C., K.E.C., D.J.R., J.J.C., M.F., V.K., A.S., E.H., W.F., B.K.H., C.T.R., F.V., J.L.G., M.M., B.L.K., S.J.W., H.A., and Y.S. edited the paper; T.S. and F.V. contributed unpublished reagents/analytic tools.

C.A. Mejias-Aponte's present address: Intramural Research Program, National Eye Institute-National Institutes of Health, Bethesda, Maryland.

The work was supported by Intramural Research Program of National Institute on Drug Abuse ZIA-DA000434-22 and ZIA-DA000069; and National Institute on Drug Abuse U01DA043098, ONR 00014-19-1-2149, and HDRF to H.A. and S.J.W. The rats bred at National Institute on Drug Abuse were registered with the Rat Genome Database (RGD #155641245) and deposited at the Rat Resource and Research Center (RRRC #975).
The authors declare no competing financial interests.
Correspondence should be addressed to Jennifer M. Bossert at jennifer.bossert{at}nih.gov or Yavin Shaham at yavin.shaham{at}nih.gov