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Featured ArticleResearch Articles, Systems/Circuits

Effect of Selective Lesions of Nucleus Accumbens µ-Opioid Receptor-Expressing Cells on Heroin Self-Administration in Male and Female Rats: A Study with Novel Oprm1-Cre Knock-in Rats

Jennifer M. Bossert, Carlos A. Mejias-Aponte, Thomas Saunders, Lindsay Altidor, Michael Emery, Ida Fredriksson, Ashley Batista, Sarah M. Claypool, Kiera E. Caldwell, David J. Reiner, Jonathan J. Chow, Matthew Foltz, Vivek Kumar, Audrey Seasholtz, Elizabeth Hughes, Wanda Filipiak, Brandon K. Harvey, Christopher T. Richie, Francois Vautier, Juan L. Gomez, Michael Michaelides, Brigitte L. Kieffer, Stanley J. Watson, Huda Akil and Yavin Shaham
Journal of Neuroscience 8 March 2023, 43 (10) 1692-1713; DOI: https://doi.org/10.1523/JNEUROSCI.2049-22.2023
Jennifer M. Bossert
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Carlos A. Mejias-Aponte
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Thomas Saunders
2University of Michigan, Ann Arbor, Michigan, 48104
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Lindsay Altidor
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Michael Emery
2University of Michigan, Ann Arbor, Michigan, 48104
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Ida Fredriksson
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Ashley Batista
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Sarah M. Claypool
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Kiera E. Caldwell
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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David J. Reiner
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Jonathan J. Chow
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Matthew Foltz
2University of Michigan, Ann Arbor, Michigan, 48104
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Vivek Kumar
2University of Michigan, Ann Arbor, Michigan, 48104
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Audrey Seasholtz
2University of Michigan, Ann Arbor, Michigan, 48104
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Elizabeth Hughes
2University of Michigan, Ann Arbor, Michigan, 48104
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Wanda Filipiak
2University of Michigan, Ann Arbor, Michigan, 48104
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Brandon K. Harvey
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Christopher T. Richie
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Francois Vautier
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Juan L. Gomez
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Michael Michaelides
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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Brigitte L. Kieffer
3University of Strasbourg–Institut National de la Santé et de la Recherche Médicale U1114, Strasbourg, France, 67084
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Stanley J. Watson
2University of Michigan, Ann Arbor, Michigan, 48104
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Huda Akil
2University of Michigan, Ann Arbor, Michigan, 48104
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Yavin Shaham
1Intramural Research Program, National Institute on Drug Abuse–National Institutes of Health, Baltimore, Maryland, 21224
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The Journal of Neuroscience: 43 (10)
Journal of Neuroscience
Vol. 43, Issue 10
8 Mar 2023
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Effect of Selective Lesions of Nucleus Accumbens µ-Opioid Receptor-Expressing Cells on Heroin Self-Administration in Male and Female Rats: A Study with Novel Oprm1-Cre Knock-in Rats
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Effect of Selective Lesions of Nucleus Accumbens µ-Opioid Receptor-Expressing Cells on Heroin Self-Administration in Male and Female Rats: A Study with Novel Oprm1-Cre Knock-in Rats
Jennifer M. Bossert, Carlos A. Mejias-Aponte, Thomas Saunders, Lindsay Altidor, Michael Emery, Ida Fredriksson, Ashley Batista, Sarah M. Claypool, Kiera E. Caldwell, David J. Reiner, Jonathan J. Chow, Matthew Foltz, Vivek Kumar, Audrey Seasholtz, Elizabeth Hughes, Wanda Filipiak, Brandon K. Harvey, Christopher T. Richie, Francois Vautier, Juan L. Gomez, Michael Michaelides, Brigitte L. Kieffer, Stanley J. Watson, Huda Akil, Yavin Shaham
Journal of Neuroscience 8 March 2023, 43 (10) 1692-1713; DOI: 10.1523/JNEUROSCI.2049-22.2023

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Effect of Selective Lesions of Nucleus Accumbens µ-Opioid Receptor-Expressing Cells on Heroin Self-Administration in Male and Female Rats: A Study with Novel Oprm1-Cre Knock-in Rats
Jennifer M. Bossert, Carlos A. Mejias-Aponte, Thomas Saunders, Lindsay Altidor, Michael Emery, Ida Fredriksson, Ashley Batista, Sarah M. Claypool, Kiera E. Caldwell, David J. Reiner, Jonathan J. Chow, Matthew Foltz, Vivek Kumar, Audrey Seasholtz, Elizabeth Hughes, Wanda Filipiak, Brandon K. Harvey, Christopher T. Richie, Francois Vautier, Juan L. Gomez, Michael Michaelides, Brigitte L. Kieffer, Stanley J. Watson, Huda Akil, Yavin Shaham
Journal of Neuroscience 8 March 2023, 43 (10) 1692-1713; DOI: 10.1523/JNEUROSCI.2049-22.2023
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Keywords

  • mu opioid receptor
  • knockin
  • CRISPR
  • heroin self-administration
  • pain
  • caspase 3 lesion

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