Article Information
- Received April 29, 2022
- Revision received February 27, 2023
- Accepted March 15, 2023
- First published April 10, 2023.
- Version of record published May 10, 2023.
Author Information
- Billy Kim1,*,
- Dowon Kim1,*,
- Anton Schulmann2,*,
- Yash Patel1,*,
- Carolina Caban-Rivera1,
- Paul Kim1,
- Ananya Jambhale1,
- Kory R. Johnson3,
- Ningping Feng1,
- Qing Xu1,
- Sun Jung Kang4,
- Ajeet Mandal1,
- Michael Kelly5,
- Nirmala Akula2,
- Francis J. McMahon2,
- Barbara Lipska1,
- Stefano Marenco1,**, and
- Pavan K. Auluck1,**
- 1Human Brain Collection Core, National Institute of Mental Health-Intramural Research Program, Bethesda, Maryland 20892
- 2Human Genetics Branch, National Institute of Mental Health-Intramural Research Program, Bethesda, Maryland 20892
- 3Information Technology and Bioinformatics Program, National Institute of Neurological Disorders and Stroke-Intramural Research Program, Bethesda, Maryland 20892
- 4Genetic Epidemiology Research Branch, National Institute of Mental Health-Intramural Research Program, Bethesda, Maryland 20892
- 5CCR Single Analysis Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Bethesda, Maryland 20892
Author contributions
Author contributions: B.K., D.K., C.C.-R., P.K., N.F., Q.X., and M.K. performed research; B.K., A.S., Y.P., A.J., K.R.J., S.J.K., A.M., B.L., S.M., and P.K.A. analyzed data; B.K. and D.K. wrote the first draft of the paper; A.S., N.A., F.J.M., B.L., and P.K.A. edited the paper; M.K. and N.A. contributed unpublished reagents/analytic tools; F.J.M., S.M., and P.K.A. designed research; S.M. and P.K.A. wrote the paper.
↵*B.K., D.K., A.S., and Y.P. contributed equally to this work.
↵**S.M. and P.K.A. contributed equally to this work.
Disclosures
- Received April 29, 2022.
- Revision received February 27, 2023.
- Accepted March 15, 2023.
This work was supported by the Intramural Research Program of the National Institute of Mental Health ZICMH002903-15. This work utilized the computational resources of the National Institutes of Health HPC Biowulf cluster (http://hpc.nih.gov). We thank the families of the deceased for tissue donations; the Offices of the Medical Examiners of Washington, D.C. and Virginia for the extraction of the tissue; the Single Cell Analysis Facility, National Cancer Institute Center for Cancer Research and the Sequencing Facility, and National Cancer Institute Center for Cancer Research for support in the snRNA-seq protocol, which are funded through the Frederick National Laboratory for Cancer Research Contract 75N91019D00024; and Advanced Cell Diagnostics for support in the RNAscope protocol.
The authors declare no competing financial interests.
- Correspondence should be addressed to Stefano Marenco at marencos{at}mail.nih.gov or Pavan K. Auluck at pavan.auluck{at}nih.gov
Funding
Intramural Research Program of the NIMH
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