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Research Articles, Cellular/Molecular

Histamine Release in the Prefrontal Cortex Excites Fast-Spiking Interneurons while GABA Released from the Same Axons Inhibits Pyramidal Cells

Diana Lucaci, Xiao Yu, Paul Chadderton, William Wisden and Stephen G. Brickley
Journal of Neuroscience 11 January 2023, 43 (2) 187-198; DOI: https://doi.org/10.1523/JNEUROSCI.0936-22.2022
Diana Lucaci
1Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom
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Xiao Yu
1Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom
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Paul Chadderton
2School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom
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William Wisden
1Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom
3UK Dementia Research Institute Center at Imperial, Imperial College London, London SW7 2AZ, United Kingdom
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Stephen G. Brickley
1Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0936-22.2022
PubMed 
36639899
Published By 
Society for Neuroscience
History 
  • Received May 16, 2022
  • Revision received September 6, 2022
  • Accepted November 3, 2022
  • First published December 8, 2022.
  • Version of record published January 11, 2023.
Copyright & Usage 
Copyright © 2023 the authors SfN exclusive license.

Author Information

  1. Diana Lucaci1,
  2. Xiao Yu1,
  3. Paul Chadderton2,
  4. William Wisden1,3, and
  5. Stephen G. Brickley1
  1. 1Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom
  2. 2School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom
  3. 3UK Dementia Research Institute Center at Imperial, Imperial College London, London SW7 2AZ, United Kingdom
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Author contributions

  1. Author contributions: P.C. and S.G.B. designed research; D.L. and X.Y. performed research; D.L. and S.G.B. analyzed data; D.L., P.C., W.W., and S.G.B. wrote the paper.

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Disclosures

    • Received May 16, 2022.
    • Revision received September 6, 2022.
    • Accepted November 3, 2022.
  • This research was funded by the Wellcome Trust (Grant 107841/Z/15/Z, to W.W.), the UK Dementia Research Institute (Grant UK DRI-5004, to W.W.), and the Biotechnology and Biological Sciences Research Council (Grant BB/N008871/1, to P.C and S.G.B.). We retain the right to deposit the accepted manuscript in a repository of their choice and on publication immediately make this manuscript green open access with a CC-BY license.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Stephen G. Brickley at s.brickley{at}imperial.ac.uk

Funding

  • Wellcome Trust (WT)

    107841/Z/15/Z
  • UK Dementia Research Institute (UK DRI)

    UK DRI-5004
  • UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)

    BB/N008871/1; BB/N008871/1

Other Version

  • previous version (December 08, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 43 (2)
Journal of Neuroscience
Vol. 43, Issue 2
11 Jan 2023
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Histamine Release in the Prefrontal Cortex Excites Fast-Spiking Interneurons while GABA Released from the Same Axons Inhibits Pyramidal Cells
Diana Lucaci, Xiao Yu, Paul Chadderton, William Wisden, Stephen G. Brickley
Journal of Neuroscience 11 January 2023, 43 (2) 187-198; DOI: 10.1523/JNEUROSCI.0936-22.2022

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Histamine Release in the Prefrontal Cortex Excites Fast-Spiking Interneurons while GABA Released from the Same Axons Inhibits Pyramidal Cells
Diana Lucaci, Xiao Yu, Paul Chadderton, William Wisden, Stephen G. Brickley
Journal of Neuroscience 11 January 2023, 43 (2) 187-198; DOI: 10.1523/JNEUROSCI.0936-22.2022
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Keywords

  • GABA
  • histamine
  • hypothalamus
  • prefrontal cortex

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