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Research Articles, Development/Plasticity/Repair

Deletion of Notch1 during Cochlear Maturation Leads to Rapid Supporting Cell Death and Profound Deafness

Alison Heffer, Felicia A. Gilels and Amy E. Kiernan
Journal of Neuroscience 11 January 2023, 43 (2) 199-210; DOI: https://doi.org/10.1523/JNEUROSCI.1090-22.2022
Alison Heffer
1Flaum Eye Institute, Department of Ophthalmology, University of Rochester Medical Center, Rochester, New York 14642
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Felicia A. Gilels
1Flaum Eye Institute, Department of Ophthalmology, University of Rochester Medical Center, Rochester, New York 14642
2Departments of Pathology and Laboratory Medicine
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Amy E. Kiernan
1Flaum Eye Institute, Department of Ophthalmology, University of Rochester Medical Center, Rochester, New York 14642
3Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1090-22.2022
PubMed 
36418183
Published By 
Society for Neuroscience
History 
  • Received June 3, 2022
  • Revision received September 14, 2022
  • Accepted November 8, 2022
  • First published November 23, 2022.
  • Version of record published January 11, 2023.
Copyright & Usage 
Copyright © 2023 the authors SfN exclusive license.

Author Information

  1. Alison Heffer1,
  2. Felicia A. Gilels1,2, and
  3. Amy E. Kiernan1,3
  1. 1Flaum Eye Institute, Department of Ophthalmology, University of Rochester Medical Center, Rochester, New York 14642
  2. 2Departments of Pathology and Laboratory Medicine
  3. 3Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642
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Author contributions

  1. Author contributions: A.H. and A.E.K. designed research; A.H. and F.A.G. performed research; A.H., F.A.G., and A.E.K. analyzed data; A.H. wrote the paper.

View Full Text

Disclosures

    • Received June 3, 2022.
    • Revision received September 14, 2022.
    • Accepted November 8, 2022.
  • This work was supported by National Institutes of Health–National Institute on Deafness and Other Communication Disorders Grants RO1 DC009250 and R01 DC017767 to A.E.K. and F31 DC018198 to F.A.G., and a departmental grant from Research to Prevent Blindness.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Amy E. Kiernan at amy_kiernan{at}urmc.rochester.edu

Funding

  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    R01 DC017767; F31 DC018198; R01 DC009250
  • Research to Prevent Blindness (RPB)

    departmental

Other Version

  • previous version (November 23, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 43 (2)
Journal of Neuroscience
Vol. 43, Issue 2
11 Jan 2023
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Deletion of Notch1 during Cochlear Maturation Leads to Rapid Supporting Cell Death and Profound Deafness
Alison Heffer, Felicia A. Gilels, Amy E. Kiernan
Journal of Neuroscience 11 January 2023, 43 (2) 199-210; DOI: 10.1523/JNEUROSCI.1090-22.2022

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Deletion of Notch1 during Cochlear Maturation Leads to Rapid Supporting Cell Death and Profound Deafness
Alison Heffer, Felicia A. Gilels, Amy E. Kiernan
Journal of Neuroscience 11 January 2023, 43 (2) 199-210; DOI: 10.1523/JNEUROSCI.1090-22.2022
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Keywords

  • cell death
  • cochlea
  • deafness
  • hair cells
  • Notch
  • supporting cells

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