Microcircuit Synchronization and Heavy-Tailed Synaptic Weight Distribution Augment preBötzinger Complex Bursting Dynamics

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¹Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095-1763
²Department of Physics & Astronomy, University of California, Los Angeles, Los Angeles, California 90095-1596
³Department of Chemistry & Biochemistry, University of California, Los Angeles, Los Angeles, California 90095-1596

S. Ashhad's present address: National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India.
V.M. Slepukhin's present addresses: Peter Debye Institute for Soft Matter Physics, Faculty of Physics and Earth Sciences, Leipzig University, 04103 Leipzig, Germany; and Department of Physics, University of California, Berkeley, Berkeley, CA 94720-7300.

Author contributions: S.A., V.M.S., J.L.F., and A.J.L. designed research; S.A. and V.M.S., performed research; S.A. and V.M.S., analyzed data; S.A., V.M.S., J.L.F., and A.J.L. wrote the paper.
↵*S.A and V.M.S. contributed equally to this work.
↵^†The senior authors J.L.F. and A.J.L. contributed equally to this work.

S. Ashhad's present address: National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India.
V.M. Slepukhin's present addresses: Peter Debye Institute for Soft Matter Physics, Faculty of Physics and Earth Sciences, Leipzig University, 04103 Leipzig, Germany; and Department of Physics, University of California, Berkeley, Berkeley, CA 94720-7300.

↵^‡In the course of final preparation of the manuscript, our friend, mentor and colleague Alex Levine passed away.
This work was supported by National Institutes of Health/National Heart, Lung, and Blood Institute Grant 1R35-HL-I35779 to J.L.F.; a Bhaumik Institute Fellowship, a Holmes-Peccei Fellowship, and Dissertation Year Fellowship to V.M.S.; and National Science Foundation Grant NSF-DMR1709785 to A.J.L. and V.M.S. We thank Dr. Kaiwen Kam for sharing previously published experimental data and Professors D.V. Buonomano and Larry Abbott, and Dr. Divyansh Mittal for critical reading and insightful comments on earlier versions of this manuscript.
The authors declare no competing financial interests.
Correspondence should be addressed to Jack L. Feldman at feldman{at}g.ucla.edu