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Research Articles, Systems/Circuits

Microcircuit Synchronization and Heavy-Tailed Synaptic Weight Distribution Augment preBötzinger Complex Bursting Dynamics

Sufyan Ashhad, Valentin M. Slepukhin, Jack L. Feldman and Alex J. Levine
Journal of Neuroscience 11 January 2023, 43 (2) 240-260; DOI: https://doi.org/10.1523/JNEUROSCI.1195-22.2022
Sufyan Ashhad
1Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095-1763
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Valentin M. Slepukhin
2Department of Physics & Astronomy, University of California, Los Angeles, Los Angeles, California 90095-1596
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Jack L. Feldman
1Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095-1763
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Alex J. Levine
2Department of Physics & Astronomy, University of California, Los Angeles, Los Angeles, California 90095-1596
3Department of Chemistry & Biochemistry, University of California, Los Angeles, Los Angeles, California 90095-1596
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1195-22.2022
PubMed 
36400528
Published By 
Society for Neuroscience
History 
  • Received June 17, 2022
  • Revision received November 5, 2022
  • Accepted November 10, 2022
  • First published November 18, 2022.
  • Version of record published January 11, 2023.
Copyright & Usage 
Copyright © 2023 the authors SfN exclusive license.

Author Information

  1. Sufyan Ashhad1,*,
  2. Valentin M. Slepukhin2,*,
  3. Jack L. Feldman1,†, and
  4. Alex J. Levine2,3,†,‡
  1. 1Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095-1763
  2. 2Department of Physics & Astronomy, University of California, Los Angeles, Los Angeles, California 90095-1596
  3. 3Department of Chemistry & Biochemistry, University of California, Los Angeles, Los Angeles, California 90095-1596
  • S. Ashhad's present address: National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India.

  • V.M. Slepukhin's present addresses: Peter Debye Institute for Soft Matter Physics, Faculty of Physics and Earth Sciences, Leipzig University, 04103 Leipzig, Germany; and Department of Physics, University of California, Berkeley, Berkeley, CA 94720-7300.

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Author contributions

  1. Author contributions: S.A., V.M.S., J.L.F., and A.J.L. designed research; S.A. and V.M.S., performed research; S.A. and V.M.S., analyzed data; S.A., V.M.S., J.L.F., and A.J.L. wrote the paper.

  2. ↵*S.A and V.M.S. contributed equally to this work.

  3. ↵†The senior authors J.L.F. and A.J.L. contributed equally to this work.

  • S. Ashhad's present address: National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India.

  • V.M. Slepukhin's present addresses: Peter Debye Institute for Soft Matter Physics, Faculty of Physics and Earth Sciences, Leipzig University, 04103 Leipzig, Germany; and Department of Physics, University of California, Berkeley, Berkeley, CA 94720-7300.

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Disclosures

    • Received June 17, 2022.
    • Revision received November 5, 2022.
    • Accepted November 10, 2022.
  • ↵‡In the course of final preparation of the manuscript, our friend, mentor and colleague Alex Levine passed away.

  • This work was supported by National Institutes of Health/National Heart, Lung, and Blood Institute Grant 1R35-HL-I35779 to J.L.F.; a Bhaumik Institute Fellowship, a Holmes-Peccei Fellowship, and Dissertation Year Fellowship to V.M.S.; and National Science Foundation Grant NSF-DMR1709785 to A.J.L. and V.M.S. We thank Dr. Kaiwen Kam for sharing previously published experimental data and Professors D.V. Buonomano and Larry Abbott, and Dr. Divyansh Mittal for critical reading and insightful comments on earlier versions of this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Jack L. Feldman at feldman{at}g.ucla.edu

Funding

  • HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

    1R35HLI35779
  • NSF | Directorate for Mathematical and Physical Sciences (MPS)

    DMR1709785
  • Holmes-Peccei Fellowship

Other Version

  • previous version (November 18, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 43 (2)
Journal of Neuroscience
Vol. 43, Issue 2
11 Jan 2023
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Microcircuit Synchronization and Heavy-Tailed Synaptic Weight Distribution Augment preBötzinger Complex Bursting Dynamics
Sufyan Ashhad, Valentin M. Slepukhin, Jack L. Feldman, Alex J. Levine
Journal of Neuroscience 11 January 2023, 43 (2) 240-260; DOI: 10.1523/JNEUROSCI.1195-22.2022

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Microcircuit Synchronization and Heavy-Tailed Synaptic Weight Distribution Augment preBötzinger Complex Bursting Dynamics
Sufyan Ashhad, Valentin M. Slepukhin, Jack L. Feldman, Alex J. Levine
Journal of Neuroscience 11 January 2023, 43 (2) 240-260; DOI: 10.1523/JNEUROSCI.1195-22.2022
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Keywords

  • attractor dynamics
  • breathing rhythm
  • graph neural network
  • motor systems
  • preBötzinger Complex
  • synchronization

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