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Featured ArticleResearch Articles, Systems/Circuits

Increased Excitability and Synaptic Plasticity of Drd1- and Drd2-Expressing Prelimbic Neurons Projecting to Nucleus Accumbens after Heroin Abstinence Are Reversed by Cue-Induced Relapse and Protein Kinase A Inhibition

Saurabh S. Kokane, Robert D. Cole, Bogdan Bordieanu, Chevin M. Ray, Ishraq A. Haque, James M. Otis and Jacqueline F. McGinty
Journal of Neuroscience 31 May 2023, 43 (22) 4019-4032; DOI: https://doi.org/10.1523/JNEUROSCI.0108-23.2023
Saurabh S. Kokane
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Robert D. Cole
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Bogdan Bordieanu
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Chevin M. Ray
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Ishraq A. Haque
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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  • ORCID record for Ishraq A. Haque
James M. Otis
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Jacqueline F. McGinty
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0108-23.2023
PubMed 
37094933
Published By 
Society for Neuroscience
History 
  • Received January 16, 2023
  • Revision received March 23, 2023
  • Accepted April 3, 2023
  • First published April 24, 2023.
  • Version of record published May 31, 2023.
Copyright & Usage 
Copyright © 2023 the authors SfN exclusive license.

Author Information

  1. Saurabh S. Kokane,
  2. Robert D. Cole,
  3. Bogdan Bordieanu,
  4. Chevin M. Ray,
  5. Ishraq A. Haque,
  6. James M. Otis, and
  7. Jacqueline F. McGinty
  1. Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Author contributions

  1. Author contributions: S.S.K., J.M.O., and J.F.M. designed research; S.S.K., R.D.C., B.B., C.M.R., and I.A.H. performed research; S.S.K. and J.M.O. analyzed data; S.S.K. wrote the paper.

Disclosures

    • Received January 16, 2023.
    • Revision received March 23, 2023.
    • Accepted April 3, 2023.
  • This work was supported by National Institutes of Health Grants P50-DA-15369 and T32-DA-07288. We thank Dr. Elizabeth Doncheck and Lisa Green for technical training and assistance. We thank Dr. Matthew Hearing for reviewing preliminary electrophysiology data and providing valuable suggestions. In addition, we thank Ayteria Crow and Caroline Limbaker (Center for Opioid and Cocaine Addiction) for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Jacqueline F. McGinty at mcginty{at}musc.edu

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    P50 DA15369; T32 DA07288

Other Version

  • previous version (April 24, 2023).
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The Journal of Neuroscience: 43 (22)
Journal of Neuroscience
Vol. 43, Issue 22
31 May 2023
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Increased Excitability and Synaptic Plasticity of Drd1- and Drd2-Expressing Prelimbic Neurons Projecting to Nucleus Accumbens after Heroin Abstinence Are Reversed by Cue-Induced Relapse and Protein Kinase A Inhibition
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Increased Excitability and Synaptic Plasticity of Drd1- and Drd2-Expressing Prelimbic Neurons Projecting to Nucleus Accumbens after Heroin Abstinence Are Reversed by Cue-Induced Relapse and Protein Kinase A Inhibition
Saurabh S. Kokane, Robert D. Cole, Bogdan Bordieanu, Chevin M. Ray, Ishraq A. Haque, James M. Otis, Jacqueline F. McGinty
Journal of Neuroscience 31 May 2023, 43 (22) 4019-4032; DOI: 10.1523/JNEUROSCI.0108-23.2023

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Increased Excitability and Synaptic Plasticity of Drd1- and Drd2-Expressing Prelimbic Neurons Projecting to Nucleus Accumbens after Heroin Abstinence Are Reversed by Cue-Induced Relapse and Protein Kinase A Inhibition
Saurabh S. Kokane, Robert D. Cole, Bogdan Bordieanu, Chevin M. Ray, Ishraq A. Haque, James M. Otis, Jacqueline F. McGinty
Journal of Neuroscience 31 May 2023, 43 (22) 4019-4032; DOI: 10.1523/JNEUROSCI.0108-23.2023
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Keywords

  • abstinence
  • dopamine receptors
  • excitability
  • heroin
  • prelimbic cortex
  • protein kinase A

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