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Featured ArticleResearch Articles, Systems/Circuits

Increased Excitability and Synaptic Plasticity of Drd1- and Drd2-Expressing Prelimbic Neurons Projecting to Nucleus Accumbens after Heroin Abstinence Are Reversed by Cue-Induced Relapse and Protein Kinase A Inhibition

Saurabh S. Kokane, Robert D. Cole, Bogdan Bordieanu, Chevin M. Ray, Ishraq A. Haque, James M. Otis and Jacqueline F. McGinty
Journal of Neuroscience 31 May 2023, 43 (22) 4019-4032; DOI: https://doi.org/10.1523/JNEUROSCI.0108-23.2023
Saurabh S. Kokane
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Robert D. Cole
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Bogdan Bordieanu
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Chevin M. Ray
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Ishraq A. Haque
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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  • ORCID record for Ishraq A. Haque
James M. Otis
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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Jacqueline F. McGinty
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425
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The Journal of Neuroscience: 43 (22)
Journal of Neuroscience
Vol. 43, Issue 22
31 May 2023
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Increased Excitability and Synaptic Plasticity of Drd1- and Drd2-Expressing Prelimbic Neurons Projecting to Nucleus Accumbens after Heroin Abstinence Are Reversed by Cue-Induced Relapse and Protein Kinase A Inhibition
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Increased Excitability and Synaptic Plasticity of Drd1- and Drd2-Expressing Prelimbic Neurons Projecting to Nucleus Accumbens after Heroin Abstinence Are Reversed by Cue-Induced Relapse and Protein Kinase A Inhibition
Saurabh S. Kokane, Robert D. Cole, Bogdan Bordieanu, Chevin M. Ray, Ishraq A. Haque, James M. Otis, Jacqueline F. McGinty
Journal of Neuroscience 31 May 2023, 43 (22) 4019-4032; DOI: 10.1523/JNEUROSCI.0108-23.2023

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Increased Excitability and Synaptic Plasticity of Drd1- and Drd2-Expressing Prelimbic Neurons Projecting to Nucleus Accumbens after Heroin Abstinence Are Reversed by Cue-Induced Relapse and Protein Kinase A Inhibition
Saurabh S. Kokane, Robert D. Cole, Bogdan Bordieanu, Chevin M. Ray, Ishraq A. Haque, James M. Otis, Jacqueline F. McGinty
Journal of Neuroscience 31 May 2023, 43 (22) 4019-4032; DOI: 10.1523/JNEUROSCI.0108-23.2023
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Keywords

  • abstinence
  • dopamine receptors
  • excitability
  • heroin
  • prelimbic cortex
  • protein kinase A

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