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Cover image

This electron micrograph shows the distribution of PI(4,5)P2 (5 nm gold particles) and Cav2.1 (12 nm gold particles) on the presynaptic parallel fiber bouton of mouse cerebellum visualized using SDS-digested freeze-fracture replica labeling. For more information, see the article by Eguchi et al. (pages 4197–4216). Cover art: Kohgaku Eguchi.