Munc 18-1 knock-out mouse brain (E18) showing cellular stress response in hippocampus and cortex by phosphorylated p53 staining (green) and cell death in the hippocampus marked by fragmented cleaved caspase 3 (red) positive nuclei (DAPI in blue). For more information, see the article by Feringa, van Berkel et al. (pages 347–358). Cover image: F. M. Feringa.