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Research Articles, Development/Plasticity/Repair

CDK5/p35-Dependent Microtubule Reorganization Contributes to Homeostatic Shortening of the Axon Initial Segment

Israt Jahan, Ryota Adachi, Ryo Egawa, Haruka Nomura and Hiroshi Kuba
Journal of Neuroscience 18 January 2023, 43 (3) 359-372; DOI: https://doi.org/10.1523/JNEUROSCI.0917-22.2022
Israt Jahan
Department of Cell Physiology, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan
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Ryota Adachi
Department of Cell Physiology, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan
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Ryo Egawa
Department of Cell Physiology, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan
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Haruka Nomura
Department of Cell Physiology, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan
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Hiroshi Kuba
Department of Cell Physiology, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0917-22.2022
PubMed 
36639893
Published By 
Society for Neuroscience
History 
  • Received May 12, 2022
  • Revision received October 13, 2022
  • Accepted October 18, 2022
  • First published December 6, 2022.
  • Version of record published January 18, 2023.
Copyright & Usage 
Copyright © 2023 the authors SfN exclusive license.

Author Information

  1. Israt Jahan*,
  2. Ryota Adachi*,
  3. Ryo Egawa,
  4. Haruka Nomura, and
  5. Hiroshi Kuba
  1. Department of Cell Physiology, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan
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Author contributions

  1. Author contributions: I.J., R.A., and H.K. designed research; I.J., R.A., R.E., H.N., and H.K. performed research; I.J., R.A., R.E., H.N., and H.K. analyzed data; H.K. wrote the paper.

  2. ↵*I.J. and R.A. contributed equally to this work.

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Disclosures

    • Received May 12, 2022.
    • Revision received October 13, 2022.
    • Accepted October 18, 2022.
  • This work was supported by Ministry of Education, Culture, Sports, Science, and Technology Grants 19H04747 and 21H02577 (H.K.) and the Takeda Science Foundation (H.K.). We thank the Division for Medical Research Engineering, Nagoya University Graduate School of Medicine, for use of NanoDrop 2000, Agilent 2100 Bioanalyzer, and the Mx3005P qPCR system.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Hiroshi Kuba at kuba{at}med.nagoya-u.ac.jp

Funding

  • Ministry of Education, Culture, Sports, Science and Technology (MEXT)

    19H04747; 21H02577
  • Takeda Science Foundation (TSF)

Other Version

  • previous version (December 06, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 43 (3)
Journal of Neuroscience
Vol. 43, Issue 3
18 Jan 2023
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CDK5/p35-Dependent Microtubule Reorganization Contributes to Homeostatic Shortening of the Axon Initial Segment
Israt Jahan, Ryota Adachi, Ryo Egawa, Haruka Nomura, Hiroshi Kuba
Journal of Neuroscience 18 January 2023, 43 (3) 359-372; DOI: 10.1523/JNEUROSCI.0917-22.2022

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CDK5/p35-Dependent Microtubule Reorganization Contributes to Homeostatic Shortening of the Axon Initial Segment
Israt Jahan, Ryota Adachi, Ryo Egawa, Haruka Nomura, Hiroshi Kuba
Journal of Neuroscience 18 January 2023, 43 (3) 359-372; DOI: 10.1523/JNEUROSCI.0917-22.2022
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Keywords

  • axon initial segment
  • Ca2+
  • CDK5
  • microtubules
  • p35
  • plasticity

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