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Research Articles, Behavioral/Cognitive

The Angiotensin Antagonist Losartan Modulates Social Reward Motivation and Punishment Sensitivity via Modulating Midbrain-Striato-Frontal Circuits

Xinqi Zhou, Ting Xu, Yixu Zeng, Ran Zhang, Ziyu Qi, Weihua Zhao, Keith M. Kendrick and Benjamin Becker
Journal of Neuroscience 18 January 2023, 43 (3) 472-483; DOI: https://doi.org/10.1523/JNEUROSCI.1114-22.2022
Xinqi Zhou
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China
2Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, 610066, China
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Ting Xu
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China
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Yixu Zeng
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China
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Ran Zhang
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China
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Ziyu Qi
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China
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Weihua Zhao
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China
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Keith M. Kendrick
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China
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Benjamin Becker
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1114-22.2022
PubMed 
36639890
Published By 
Society for Neuroscience
History 
  • Received June 10, 2022
  • Revision received October 12, 2022
  • Accepted November 17, 2022
  • First published December 6, 2022.
  • Version of record published January 18, 2023.
Copyright & Usage 
Copyright © 2023 the authors SfN exclusive license.

Author Information

  1. Xinqi Zhou1,2,
  2. Ting Xu1,
  3. Yixu Zeng1,
  4. Ran Zhang1,
  5. Ziyu Qi1,
  6. Weihua Zhao1,
  7. Keith M. Kendrick1, and
  8. Benjamin Becker1
  1. 1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China
  2. 2Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, 610066, China
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Author contributions

  1. Author contributions: X.Z. and B.B. designed research; X.Z., T.X., Y.Z., R.Z., and Z.Q. performed research; X.Z. analyzed data; X.Z. wrote the first draft of the paper; X.Z., W.Z., K.M.K., and B.B. edited the paper; X.Z. and B.B. wrote the paper.

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Disclosures

    • Received June 10, 2022.
    • Revision received October 12, 2022.
    • Accepted November 17, 2022.
  • This work was supported by National Natural Science Foundation (NSFC) Grants 82271583 and 32250610208, the Ministry of Science and Technology Brain Project 2022ZD0208500 (MOST2030), and the National Key Research and Development Program Grant 2018YFA0701400 of China.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Benjamin Becker at ben_becker{at}gmx.de

Funding

  • MOST | National Key Research and Development Program of China (NKPs)

    2018YFA0701400
  • National Natural Science Foundation of China (NSFC)

    82271583; 32250610208
  • Ministry of Science and Technology (Brain Project)

    2022ZD0208500

Other Version

  • previous version (December 06, 2022).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 43 (3)
Journal of Neuroscience
Vol. 43, Issue 3
18 Jan 2023
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The Angiotensin Antagonist Losartan Modulates Social Reward Motivation and Punishment Sensitivity via Modulating Midbrain-Striato-Frontal Circuits
Xinqi Zhou, Ting Xu, Yixu Zeng, Ran Zhang, Ziyu Qi, Weihua Zhao, Keith M. Kendrick, Benjamin Becker
Journal of Neuroscience 18 January 2023, 43 (3) 472-483; DOI: 10.1523/JNEUROSCI.1114-22.2022

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The Angiotensin Antagonist Losartan Modulates Social Reward Motivation and Punishment Sensitivity via Modulating Midbrain-Striato-Frontal Circuits
Xinqi Zhou, Ting Xu, Yixu Zeng, Ran Zhang, Ziyu Qi, Weihua Zhao, Keith M. Kendrick, Benjamin Becker
Journal of Neuroscience 18 January 2023, 43 (3) 472-483; DOI: 10.1523/JNEUROSCI.1114-22.2022
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Keywords

  • dopamine
  • losartan
  • social reward
  • striatum
  • ventral tegmental area

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