Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
Research Articles, Systems/Circuits

2-AG-Mediated Control of GABAergic Signaling Is Impaired in a Model of Epilepsy

Roberto Colangeli, Maria Morena, Allison Werner, Roger J. Thompson, Mario van der Stelt, Quentin J. Pittman, Matthew N. Hill and G. Campbell Teskey
Journal of Neuroscience 25 January 2023, 43 (4) 571-583; DOI: https://doi.org/10.1523/JNEUROSCI.0541-22.2022
Roberto Colangeli
1Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada
2Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126 Ancona, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Morena
1Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada
3Department of Physiology and Pharmacolgy, Sapienza University of Rome, 00185 Rome, Italy
4Neuropsychopharmacology Unit, Santa Lucia Foundation, 00143 Rome, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Maria Morena
Allison Werner
1Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roger J. Thompson
1Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mario van der Stelt
5Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, 2333 CC, Leiden, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Quentin J. Pittman
6Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N4N1, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Quentin J. Pittman
Matthew N. Hill
1Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Campbell Teskey
1Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada
6Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N4N1, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Campbell Teskey
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0541-22.2022
PubMed 
36460464
Published By 
Society for Neuroscience
History 
  • Received March 17, 2022
  • Revision received October 21, 2022
  • Accepted November 25, 2022
  • First published December 2, 2022.
  • Version of record published January 25, 2023.
Copyright & Usage 
Copyright © 2023 the authors SfN exclusive license.

Author Information

  1. Roberto Colangeli1,2,
  2. Maria Morena1,3,4,
  3. Allison Werner1,
  4. Roger J. Thompson1,
  5. Mario van der Stelt5,
  6. Quentin J. Pittman6,
  7. Matthew N. Hill1, and
  8. G. Campbell Teskey1,6
  1. 1Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary AB T2N4N1, Canada
  2. 2Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126 Ancona, Italy
  3. 3Department of Physiology and Pharmacolgy, Sapienza University of Rome, 00185 Rome, Italy
  4. 4Neuropsychopharmacology Unit, Santa Lucia Foundation, 00143 Rome, Italy
  5. 5Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, 2333 CC, Leiden, The Netherlands
  6. 6Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N4N1, Canada
View Full Text

Author contributions

  1. Author contributions: R.C., M.M., and G.C.T. designed research; R.C., M.M. and A.W. performed research; R.C., M.M., A.W., and R.J.T. analyzed data; R.C. wrote the paper; M.M., R.J.T., M.v.d.S., Q.J.P., M.N.H., and G.C.T., edited the paper.

View Full Text

Disclosures

    • Received March 17, 2022.
    • Revision received October 21, 2022.
    • Accepted November 25, 2022.
  • This work was supported by Canadian Institutes for Health Research (CIHR) Grants MOP-130495 (G.C.T. and M.N.H.) and PJT-159454 (to Q.J.P.). R.C. received salary support from an Eyes High postdoctoral fellowship. M.M. received salary support from Alberta Innovates and CIHR postdoctoral fellowships.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Roberto Colangeli at r.colangeli{at}univpm.it

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)

    MOP-130495; PJT-159454
  • Alberta Innovates - Health Solutions (AIHS)

    PDF

Other Version

  • previous version (December 02, 2022).
  • You are viewing the most recent version of this article.

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2023-03-23
to
E.g., 2023-03-23

Article usage: December 2022 to March 2023

AbstractFullPdf
Dec 2022251026
Total 2022251026
Jan 2023124311663
Feb 20235875739
Mar 2023123196
Total 20231953192108
Total2204192134
Back to top

In this issue

The Journal of Neuroscience: 43 (4)
Journal of Neuroscience
Vol. 43, Issue 4
25 Jan 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Masthead (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
2-AG-Mediated Control of GABAergic Signaling Is Impaired in a Model of Epilepsy
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
2-AG-Mediated Control of GABAergic Signaling Is Impaired in a Model of Epilepsy
Roberto Colangeli, Maria Morena, Allison Werner, Roger J. Thompson, Mario van der Stelt, Quentin J. Pittman, Matthew N. Hill, G. Campbell Teskey
Journal of Neuroscience 25 January 2023, 43 (4) 571-583; DOI: 10.1523/JNEUROSCI.0541-22.2022

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
2-AG-Mediated Control of GABAergic Signaling Is Impaired in a Model of Epilepsy
Roberto Colangeli, Maria Morena, Allison Werner, Roger J. Thompson, Mario van der Stelt, Quentin J. Pittman, Matthew N. Hill, G. Campbell Teskey
Journal of Neuroscience 25 January 2023, 43 (4) 571-583; DOI: 10.1523/JNEUROSCI.0541-22.2022
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • electrophysiology
  • endocannabinoids
  • epilepsy
  • GABA
  • kindling
  • synaptic plasticity

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Articles

  • Macrophages Promote Repair of Inner Hair Cell Ribbon Synapses following Noise-Induced Cochlear Synaptopathy
  • The Basolateral Amygdala Sends a Mixed (GABAergic and Glutamatergic) Projection to the Mediodorsal Thalamic Nucleus
  • Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults
Show more Research Articles

Systems/Circuits

  • Dorsolateral Striatum is a Bottleneck for Responding to Task-Relevant Stimuli in a Learned Whisker Detection Task in Mice
  • The Basolateral Amygdala Sends a Mixed (GABAergic and Glutamatergic) Projection to the Mediodorsal Thalamic Nucleus
  • A Short Route for Reach Planning between Human V6A and the Motor Cortex
Show more Systems/Circuits
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2023 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.