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Featured ArticleResearch Articles, Cellular/Molecular

Indirect Effects of Halorhodopsin Activation: Potassium Redistribution, Nonspecific Inhibition, and Spreading Depolarization

R. Ryley Parrish, Connie MacKenzie-Gray Scott, Tom Jackson-Taylor, Alex Grundmann, Faye McLeod, Neela K. Codadu, Alexandru Călin, Hannah Alfonsa, Rob C. Wykes, Juha Voipio and Andrew J. Trevelyan
Journal of Neuroscience 1 February 2023, 43 (5) 685-692; https://doi.org/10.1523/JNEUROSCI.1141-22.2022
R. Ryley Parrish
1Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
2Department of Cell Biology and Physiology, Brigham Young University, Provo 84602, Utah
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Connie MacKenzie-Gray Scott
1Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
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Tom Jackson-Taylor
1Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
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Alex Grundmann
1Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
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Faye McLeod
1Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
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Neela K. Codadu
4Queen Square Institute of Neurology, University College London, WC1N 3BG, United Kingdom
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Alexandru Călin
1Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
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Hannah Alfonsa
1Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
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Rob C. Wykes
3Nanomedicine Lab, University of Manchester, Manchester, M13 9PL, United Kingdom
4Queen Square Institute of Neurology, University College London, WC1N 3BG, United Kingdom
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Juha Voipio
5Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences, University of Helsinki, Helsinki, 00014, Finland
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Andrew J. Trevelyan
1Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
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The Journal of Neuroscience: 43 (5)
Journal of Neuroscience
Vol. 43, Issue 5
1 Feb 2023
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Indirect Effects of Halorhodopsin Activation: Potassium Redistribution, Nonspecific Inhibition, and Spreading Depolarization
R. Ryley Parrish, Connie MacKenzie-Gray Scott, Tom Jackson-Taylor, Alex Grundmann, Faye McLeod, Neela K. Codadu, Alexandru Călin, Hannah Alfonsa, Rob C. Wykes, Juha Voipio, Andrew J. Trevelyan
Journal of Neuroscience 1 February 2023, 43 (5) 685-692; DOI: 10.1523/JNEUROSCI.1141-22.2022

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Indirect Effects of Halorhodopsin Activation: Potassium Redistribution, Nonspecific Inhibition, and Spreading Depolarization
R. Ryley Parrish, Connie MacKenzie-Gray Scott, Tom Jackson-Taylor, Alex Grundmann, Faye McLeod, Neela K. Codadu, Alexandru Călin, Hannah Alfonsa, Rob C. Wykes, Juha Voipio, Andrew J. Trevelyan
Journal of Neuroscience 1 February 2023, 43 (5) 685-692; DOI: 10.1523/JNEUROSCI.1141-22.2022
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Keywords

  • chloride
  • halorhodopsin
  • potassium
  • pyramidal cells
  • spreading depression

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