mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures

Erin R. Cullen; Kamran Tariq; Amy N. Shore; Bryan W. Luikart; Matthew C. Weston

doi:10.1523/JNEUROSCI.1354-22.2022

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mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures

Erin R. Cullen, Kamran Tariq, Amy N. Shore, Bryan W. Luikart and Matthew C. Weston

Journal of Neuroscience 1 February 2023, 43 (5) 827-845; DOI: https://doi.org/10.1523/JNEUROSCI.1354-22.2022

Erin R. Cullen

1Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405

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Kamran Tariq

2Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755

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Amy N. Shore

1Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405

3Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia 24016

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Bryan W. Luikart

2Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755

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Matthew C. Weston

1Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405

3Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia 24016

4School of Neuroscience, Virginia Polytechnic and State University, Blacksburg, Virginia 24061

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mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures

Erin R. Cullen, Kamran Tariq, Amy N. Shore, Bryan W. Luikart, Matthew C. Weston

Journal of Neuroscience 1 February 2023, 43 (5) 827-845; DOI: 10.1523/JNEUROSCI.1354-22.2022

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mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures

Erin R. Cullen, Kamran Tariq, Amy N. Shore, Bryan W. Luikart, Matthew C. Weston

Journal of Neuroscience 1 February 2023, 43 (5) 827-845; DOI: 10.1523/JNEUROSCI.1354-22.2022

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dentate gyrus
epilepsy
mTOR
mTORC1
mTORC2
synaptic transmission

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