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Research Articles, Neurobiology of Disease

mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures

Erin R. Cullen, Kamran Tariq, Amy N. Shore, Bryan W. Luikart and Matthew C. Weston
Journal of Neuroscience 1 February 2023, 43 (5) 827-845; DOI: https://doi.org/10.1523/JNEUROSCI.1354-22.2022
Erin R. Cullen
1Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405
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Kamran Tariq
2Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755
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Amy N. Shore
1Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405
3Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia 24016
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Bryan W. Luikart
2Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755
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Matthew C. Weston
1Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405
3Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia 24016
4School of Neuroscience, Virginia Polytechnic and State University, Blacksburg, Virginia 24061
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The Journal of Neuroscience: 43 (5)
Journal of Neuroscience
Vol. 43, Issue 5
1 Feb 2023
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mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures
Erin R. Cullen, Kamran Tariq, Amy N. Shore, Bryan W. Luikart, Matthew C. Weston
Journal of Neuroscience 1 February 2023, 43 (5) 827-845; DOI: 10.1523/JNEUROSCI.1354-22.2022

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mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures
Erin R. Cullen, Kamran Tariq, Amy N. Shore, Bryan W. Luikart, Matthew C. Weston
Journal of Neuroscience 1 February 2023, 43 (5) 827-845; DOI: 10.1523/JNEUROSCI.1354-22.2022
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Keywords

  • dentate gyrus
  • epilepsy
  • mTOR
  • mTORC1
  • mTORC2
  • synaptic transmission

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