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Research Articles, Neurobiology of Disease

NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine

Panos Zanos, Kyle A. Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A. Zarate Jr, Scott M. Thompson and Todd D. Gould
Journal of Neuroscience 8 February 2023, 43 (6) 1038-1050; DOI: https://doi.org/10.1523/JNEUROSCI.1316-22.2022
Panos Zanos
1Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland 21201
2Department of Psychology, University of Cyprus, Nicosia 2109, Cyprus
5Department of Physiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201
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Kyle A. Brown
1Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland 21201
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Polymnia Georgiou
1Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland 21201
3Department of Biology, University of Cyprus, Nicosia 2109, Cyprus
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Peixiong Yuan
4Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892
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Carlos A. Zarate Jr
4Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892
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Scott M. Thompson
1Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland 21201
5Department of Physiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201
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Todd D. Gould
1Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland 21201
6Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, Maryland 21201
7Department of Anatomy & Neurobiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201
8Veterans Affairs Maryland Health Care System, Baltimore, Maryland 21201
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1316-22.2022
PubMed 
36596696
Published By 
Society for Neuroscience
History 
  • Received July 4, 2022
  • Revision received November 30, 2022
  • Accepted December 18, 2022
  • First published January 3, 2023.
  • Version of record published February 8, 2023.
Copyright & Usage 
Copyright © 2023 the authors SfN exclusive license.

Author Information

  1. Panos Zanos1,2,5,
  2. Kyle A. Brown1,
  3. Polymnia Georgiou1,3,
  4. Peixiong Yuan4,
  5. Carlos A. Zarate Jr4,
  6. Scott M. Thompson1,5, and
  7. Todd D. Gould1,6,7,8
  1. 1Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland 21201
  2. 2Department of Psychology, University of Cyprus, Nicosia 2109, Cyprus
  3. 3Department of Biology, University of Cyprus, Nicosia 2109, Cyprus
  4. 4Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892
  5. 5Department of Physiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201
  6. 6Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, Maryland 21201
  7. 7Department of Anatomy & Neurobiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201
  8. 8Veterans Affairs Maryland Health Care System, Baltimore, Maryland 21201
  • Scott M. Thompson's present address: Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colorado 80045.

  • Polymnia Georgiou's present address: Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 52311.

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Author contributions

  1. Author contributions: P.Z., K.A.B., C.A.Z., S.M.T., and T.D.G. designed research; P.Z., K.A.B., P.G., and P.Y. performed research; P.Z. analyzed data; P.Z. and T.D.G. wrote the first draft of the paper; K.A.B., P.G., P.Y., C.A.Z., and S.M.T. edited the paper.

  • Scott M. Thompson's present address: Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colorado 80045.

  • Polymnia Georgiou's present address: Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 52311.

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Disclosures

    • Received July 4, 2022.
    • Revision received November 30, 2022.
    • Accepted December 18, 2022.
  • This research was supported by the National Institutes of Health Grant MH107615, United States Department of Veterans Affairs Merit Awards 1I01BX004062 and 101BX003631, an Allergan Pharmaceuticals Investigator-Initiated Research Grant (T.D.G.), the National Institutes of Health Grant MH086828 (to S.M.T.), and the Brain and Research Foundation Young Investigator Grant National Alliance for Research on Schizophrenia and Depression Grant 26826 (to P.Z.). We thank Ms. Thatchana Rajasekar for her technical assistance in analyzing the novel object recognition experiments. We also thank Dr. Patrick Morris who characterized the GluN2A PAM, GNE-5729.

  • T.D.G. has received research funding from Roche Pharmaceuticals and served as a consultant for FSV7 LLC, during the preceding three years. C.A.Z. is listed as a co-inventor on a patent for the use of ketamine in major depression and suicidal ideation. P.Z., C.A.Z., and T.D.G. are listed as co-authors in patents and patent applications related to the pharmacology and use of (2R,6R)-HNK in the treatment of depression, anxiety, anhedonia, suicidal ideation, and posttraumatic stress disorders. S.M.T. is listed as an inventor on a patent for the use of GABA-NAMs for treatment of depression. All other authors declare no competing financial interests. C.A.Z. has assigned his patent rights to the Unites States Government but will share a percentage of any royalties that may be received. P.Z., S.M.T., and T.D.G. have assigned patent rights to the University of Maryland, Baltimore, MD, but will share a percentage of any royalties that may be received by the University of Maryland.

  • Correspondence should be addressed to Todd D. Gould at gouldlab{at}me.com or Panos Zanos at zanos.panos{at}ucy.ac.cy

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    MH107615; MH086828; MH086828
  • veterans administration

    1I01BX004062; 101BX003631
  • Brain and Research Foundation

    26826

Other Version

  • previous version (January 03, 2023).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 43 (6)
Journal of Neuroscience
Vol. 43, Issue 6
8 Feb 2023
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NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine
Panos Zanos, Kyle A. Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A. Zarate Jr, Scott M. Thompson, Todd D. Gould
Journal of Neuroscience 8 February 2023, 43 (6) 1038-1050; DOI: 10.1523/JNEUROSCI.1316-22.2022

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NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine
Panos Zanos, Kyle A. Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A. Zarate Jr, Scott M. Thompson, Todd D. Gould
Journal of Neuroscience 8 February 2023, 43 (6) 1038-1050; DOI: 10.1523/JNEUROSCI.1316-22.2022
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Keywords

  • AMPA receptor
  • antidepressant
  • hydroxynorketamine
  • ketamine
  • LTP
  • NMDA receptor

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