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Research Articles, Systems/Circuits

A Novel Mechanism for T1R-Independent Taste Responses to Concentrated Sugars

B. Kalyanasundar, Ginger D. Blonde, Alan C. Spector and Susan P. Travers
Journal of Neuroscience 8 February 2023, 43 (6) 965-978; DOI: https://doi.org/10.1523/JNEUROSCI.1760-22.2023
B. Kalyanasundar
1Division of Biosciences, College of Dentistry, Ohio State University, Columbus, Ohio, 43210-1267
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Ginger D. Blonde
2Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida, 32306-4301
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Alan C. Spector
2Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida, 32306-4301
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Susan P. Travers
1Division of Biosciences, College of Dentistry, Ohio State University, Columbus, Ohio, 43210-1267
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1760-22.2023
PubMed 
36623875
Published By 
Society for Neuroscience
History 
  • Received September 15, 2022
  • Revision received December 22, 2022
  • Accepted January 3, 2023
  • First published January 9, 2023.
  • Version of record published February 8, 2023.
Copyright & Usage 
Copyright © 2023 the authors SfN exclusive license.

Author Information

  1. B. Kalyanasundar1,
  2. Ginger D. Blonde2,
  3. Alan C. Spector2, and
  4. Susan P. Travers1
  1. 1Division of Biosciences, College of Dentistry, Ohio State University, Columbus, Ohio, 43210-1267
  2. 2Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida, 32306-4301
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Author contributions

  1. Author contributions: B.K., G.D.B., A.C.S., and S.P.T. designed research; B.K. performed research; G.D.B. and A.C.S. contributed unpublished reagents/analytic tools; B.K. and S.P.T. analyzed data; B.K. and S.P.T. wrote the first draft of the paper; B.K., G.D.B., A.C.S., and S.P.T. edited the paper; B.K., A.C.S., and S.P.T. wrote the paper.

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Disclosures

    • Received September 15, 2022.
    • Revision received December 22, 2022.
    • Accepted January 3, 2023.
  • This work was supported by the National Institute of Health Grant DC004574 (to A.C.S.). We thank Dr. Joseph B. Travers for his valuable comments on the initial manuscript; Cemaliye Semmedi, Andrew Harley, and Charlotte Klimovich for excellent technical assistance; the Zuker laboratory for providing the original breeding pairs; and the Spector laboratory for generating the dbl KOs.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Susan P. Travers at travers.3{at}osu.edu

Funding

  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    DC004574

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  • previous version (January 09, 2023).
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The Journal of Neuroscience: 43 (6)
Journal of Neuroscience
Vol. 43, Issue 6
8 Feb 2023
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A Novel Mechanism for T1R-Independent Taste Responses to Concentrated Sugars
B. Kalyanasundar, Ginger D. Blonde, Alan C. Spector, Susan P. Travers
Journal of Neuroscience 8 February 2023, 43 (6) 965-978; DOI: 10.1523/JNEUROSCI.1760-22.2023

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A Novel Mechanism for T1R-Independent Taste Responses to Concentrated Sugars
B. Kalyanasundar, Ginger D. Blonde, Alan C. Spector, Susan P. Travers
Journal of Neuroscience 8 February 2023, 43 (6) 965-978; DOI: 10.1523/JNEUROSCI.1760-22.2023
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Keywords

  • broadly-tuned taste neurons
  • hyperosmotic sugars
  • parabrachial nucleus
  • Type 1 taste receptors
  • Type III taste bud cells

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