USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m6A Modification of YAP1 mRNA

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¹Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
²Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China
³Department of Human Anatomy, Nanjing Medical University, Nanjing, Jiangsu 211166, China
⁴Department of Pharmacology, China Pharmaceutical University, Nanjing 211198, China
⁵Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China

Author contributions: W.C. and X.G. designed research; X.G., W.Y., M.C., J.Z., C.X., and W.L. performed research; X.Z. and X.C. contributed unpublished reagents/analytic tools; W.C., X.G., W.Y., Y.Z., J.Z., C.X., D.J., P.T., J.W., Z.W., C.J., X.C., and W.L. analyzed data; W.C., X.G., and W.L. wrote the paper.
*X.G., W.Y., and Y.Z. contributed equally to this work.

This work was supported by National Natural Science Foundation of China Grants 81974335 and 82172426. We thank the Core Facility of the First Affiliated Hospital of Nanjing Medical University for help with the experiment.
The authors declared no competing financial interests.
Correspondence should be addressed to Weihua Cai at caiwhspine{at}sina.com or Wei Liu at weiliuspine{at}sina.com or Xiaojian Cao at xiaojiancao001{at}163.com

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