Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion

This work was supported by National Institutes of Health Grants MH061876 and NS097362 to E.R.C. C.S.E. was supported in part by a PhRMA Foundation predoctoral fellowship and University of Wisconsin–Madison Molecular and Cellular Pharmacology Training Grant T32 GM008688. E.R.C. is an Investigator of the Howard Hughes Medical Institute. This article is subject to HHMI’s Open Access to Publications policy. HHMI laboratory heads have previously granted a nonexclusive CC BY 4.0 license to the public and a sublicensable license to HHMI in their research articles. Pursuant to those licenses, the author-accepted manuscript of this article can be made freely available under a CC BY 4.0 license immediately upon publication. The data that support the findings of this study are available from the corresponding author upon reasonable request. We thank members of the E.R.C. laboratory and Kathryn Bjornson for insightful comments and valuable discussion related to the manuscript; Devin Larson and Christina Greer for maintaining the mouse colonies used for this research; Marina Caliendo for generating the full-length SYT9 Ca²⁺ ligand mutant constructs; and Wynnie Nguyen for generating the purified recombinant full-length SYT9.