Article Information
- Received September 29, 2022
- Revision received January 5, 2023
- Accepted January 10, 2023
- First published February 2, 2023.
- Version of record published March 1, 2023.
Author Information
- 1Howard Hughes Medical Institute and Department of Neuroscience, University of Wisconsin–Madison School of Medicine and Public Health, Madison, Wisconsin 53705
- 2Neuroscience Training Program, University of Wisconsin–Madison School of Medicine and Public Health, Madison, Wisconsin 53705
- 3Department of Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710
Author contributions
Author contributions: M.J.S. and E.R.C. designed research; M.J.S., C.S.E., K.S.S., and Z.W. performed research; M.J.S., C.S.E., K.S.S., and Z.W. analyzed data; M.J.S. and E.R.C. wrote the first draft of the paper; M.J.S. and E.R.C. edited the paper; M.J.S. and E.R.C. wrote the paper; E.R.C. contributed unpublished reagents/analytic tools.
Disclosures
- Received September 29, 2022.
- Revision received January 5, 2023.
- Accepted January 10, 2023.
This work was supported by National Institutes of Health Grants MH061876 and NS097362 to E.R.C. C.S.E. was supported in part by a PhRMA Foundation predoctoral fellowship and University of Wisconsin–Madison Molecular and Cellular Pharmacology Training Grant T32 GM008688. E.R.C. is an Investigator of the Howard Hughes Medical Institute. This article is subject to HHMI’s Open Access to Publications policy. HHMI laboratory heads have previously granted a nonexclusive CC BY 4.0 license to the public and a sublicensable license to HHMI in their research articles. Pursuant to those licenses, the author-accepted manuscript of this article can be made freely available under a CC BY 4.0 license immediately upon publication. The data that support the findings of this study are available from the corresponding author upon reasonable request. We thank members of the E.R.C. laboratory and Kathryn Bjornson for insightful comments and valuable discussion related to the manuscript; Devin Larson and Christina Greer for maintaining the mouse colonies used for this research; Marina Caliendo for generating the full-length SYT9 Ca2+ ligand mutant constructs; and Wynnie Nguyen for generating the purified recombinant full-length SYT9.
The authors declare no competing financial interests.
- Correspondence should be addressed to Edwin R. Chapman at chapman{at}wisc.edu
Funding
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
NS097362HHS | NIH | National Institute of Mental Health (NIMH)
MH061876Howard Hughes Medical Institute (HHMI)
HHS | NIH | National Institute of General Medical Sciences (NIGMS)
GM008688
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