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Research Articles, Behavioral/Cognitive

The Neurobiology of Life Course Socioeconomic Conditions and Associated Cognitive Performance in Middle to Late Adulthood

Stephanie Schrempft, Olga Trofimova, Morgane Künzi, Cristina Ramponi, Antoine Lutti, Ferath Kherif, Adeliya Latypova, Peter Vollenweider, Pedro Marques-Vidal, Martin Preisig, Matthias Kliegel, Silvia Stringhini and Bogdan Draganski
Journal of Neuroscience 24 April 2024, 44 (17) e1231232024; https://doi.org/10.1523/JNEUROSCI.1231-23.2024
Stephanie Schrempft
1Unit of Population Epidemiology, Division of Primary Care, Geneva University Hospitals, Geneva CH-1205, Switzerland
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  • ORCID record for Stephanie Schrempft
Olga Trofimova
2Laboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland
3Department of Computational Biology, University of Lausanne, Lausanne CH-1015, Switzerland
4Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland
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Morgane Künzi
5Swiss National Centre of Competences in Research, “LIVES - Overcoming Vulnerability: Life Course Perspectives,” University of Lausanne and University of Geneva, Lausanne CH-1015 and Carouge CH-1227, Switzerland
6Department of Psychology, University of Geneva, Geneva CH-1205, Switzerland
7Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Carouge CH-1227, Switzerland
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Cristina Ramponi
2Laboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland
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Antoine Lutti
2Laboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland
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Ferath Kherif
2Laboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland
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Adeliya Latypova
2Laboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland
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Peter Vollenweider
8Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland
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Pedro Marques-Vidal
8Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland
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  • ORCID record for Pedro Marques-Vidal
Martin Preisig
9Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne CH-1008, Switzerland
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Matthias Kliegel
5Swiss National Centre of Competences in Research, “LIVES - Overcoming Vulnerability: Life Course Perspectives,” University of Lausanne and University of Geneva, Lausanne CH-1015 and Carouge CH-1227, Switzerland
6Department of Psychology, University of Geneva, Geneva CH-1205, Switzerland
7Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Carouge CH-1227, Switzerland
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Silvia Stringhini
1Unit of Population Epidemiology, Division of Primary Care, Geneva University Hospitals, Geneva CH-1205, Switzerland
10Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva CH-1211, Switzerland
11University Centre for General Medicine and Public Health, University of Lausanne, Lausanne CH-1005, Switzerland
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Bogdan Draganski
2Laboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland
12Neurology Department, Max-Planck-Institute for Human Cognitive and Brain Sciences, D-04303 Leipzig, Germany
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1231-23.2024
PubMed 
38499361
Published By 
Society for Neuroscience
History 
  • Received July 3, 2023
  • Revision received January 18, 2024
  • Accepted January 23, 2024
  • First published March 18, 2024.
  • Version of record published April 24, 2024.
Copyright & Usage 
Copyright © 2024 the authors SfN exclusive license.

Author Information

  1. Stephanie Schrempft1,
  2. Olga Trofimova2,3,4,
  3. Morgane Künzi5,6,7,
  4. Cristina Ramponi2,
  5. Antoine Lutti2,
  6. Ferath Kherif2,
  7. Adeliya Latypova2,
  8. Peter Vollenweider8,
  9. Pedro Marques-Vidal8,
  10. Martin Preisig9,
  11. Matthias Kliegel5,6,7,
  12. Silvia Stringhini1,10,11,*, and
  13. Bogdan Draganski2,12,*
  1. 1Unit of Population Epidemiology, Division of Primary Care, Geneva University Hospitals, Geneva CH-1205, Switzerland
  2. 2Laboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland
  3. 3Department of Computational Biology, University of Lausanne, Lausanne CH-1015, Switzerland
  4. 4Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland
  5. 5Swiss National Centre of Competences in Research, “LIVES - Overcoming Vulnerability: Life Course Perspectives,” University of Lausanne and University of Geneva, Lausanne CH-1015 and Carouge CH-1227, Switzerland
  6. 6Department of Psychology, University of Geneva, Geneva CH-1205, Switzerland
  7. 7Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Carouge CH-1227, Switzerland
  8. 8Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland
  9. 9Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne CH-1008, Switzerland
  10. 10Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva CH-1211, Switzerland
  11. 11University Centre for General Medicine and Public Health, University of Lausanne, Lausanne CH-1005, Switzerland
  12. 12Neurology Department, Max-Planck-Institute for Human Cognitive and Brain Sciences, D-04303 Leipzig, Germany
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Author contributions

  1. Author contributions: Stephanie Schrempft, O.T., M.K., M.K., Silvia Stringhini, and B.D. designed research; Stephanie Schrempft, O.T., C.R., A.L., P.V., P.M-V., and M.P. performed research; O.T., A.L., F.K., and A.L. contributed unpublished reagents/analytic tools; Stephanie Schrempft analyzed data; Stephanie Schrempft wrote the paper.

Disclosures

    • Received July 3, 2023.
    • Revision received January 18, 2024.
    • Accepted January 23, 2024.
  • This work was supported by the Leenaards Foundation Scientific Prize, awarded to S.S., M.K., and B.D. The CoLaus|PsyCoLaus study was supported by research grants from GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, the Swiss National Science Foundation (Grants 3200B0_105993, 3200B0_118308, 33CSCO_122661, 33CS30_139468, 33CS30_148401, 33CS30_177535, 3247730_204523, 32003B_135679, 32003B_159780, 324730_192755, and CRSK-3_190185), the ERA-NET iSEE project, and the Swiss Personalized Health Network (Swiss Ageing Citizen Reference). LREN is very grateful to the ROGER DE SPOELBERCH and Partridge Foundations for their generous financial support. We thank those who participated in the CoLaus|PsyCoLaus study, as well as all of those who made the CoLaus|PsyCoLaus study possible.

  • ↵*Silvia Stringhini and B.D. contributed equally to this work.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Stephanie Schrempft at stephanie.schrempft{at}hcuge.ch.

Funding

  • Fondation Leenaards (Leenaards Foundation)

Other Version

  • previous version (March 18, 2024).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 44 (17)
Journal of Neuroscience
Vol. 44, Issue 17
24 Apr 2024
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The Neurobiology of Life Course Socioeconomic Conditions and Associated Cognitive Performance in Middle to Late Adulthood
Stephanie Schrempft, Olga Trofimova, Morgane Künzi, Cristina Ramponi, Antoine Lutti, Ferath Kherif, Adeliya Latypova, Peter Vollenweider, Pedro Marques-Vidal, Martin Preisig, Matthias Kliegel, Silvia Stringhini, Bogdan Draganski
Journal of Neuroscience 24 April 2024, 44 (17) e1231232024; DOI: 10.1523/JNEUROSCI.1231-23.2024

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The Neurobiology of Life Course Socioeconomic Conditions and Associated Cognitive Performance in Middle to Late Adulthood
Stephanie Schrempft, Olga Trofimova, Morgane Künzi, Cristina Ramponi, Antoine Lutti, Ferath Kherif, Adeliya Latypova, Peter Vollenweider, Pedro Marques-Vidal, Martin Preisig, Matthias Kliegel, Silvia Stringhini, Bogdan Draganski
Journal of Neuroscience 24 April 2024, 44 (17) e1231232024; DOI: 10.1523/JNEUROSCI.1231-23.2024
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Keywords

  • brain white matter microstructure
  • cognition
  • social inequalities

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