Pictured is an average MRI image of the group-wide volume increases to the hippocampus of middle-aged beagles over three years. Jessica Noche et al. tested the effects of long-term calcineurin inhibitor treatment and behavioral enrichment on structural brain changes in beagles as a model of aging and Alzheimer's disease. See the article by Noche et al. for more information. Cover image: Jessica Noche.