Arachidonic Acid Mobilization and Peroxidation Promote Microglial Dysfunction in Aβ Pathology

Da Lin; Andrew Gold; Sarah Kaye; Jeffrey R. Atkinson; Marcus Tol; Andrew Sas; Benjamin Segal; Peter Tontonoz; Jiangjiang Zhu; Jie Gao

doi:10.1523/JNEUROSCI.0202-24.2024

Research Articles, Neurobiology of Disease

Arachidonic Acid Mobilization and Peroxidation Promote Microglial Dysfunction in Aβ Pathology

Da Lin, Andrew Gold, Sarah Kaye, Jeffrey R. Atkinson, Marcus Tol, Andrew Sas, Benjamin Segal, Peter Tontonoz, Jiangjiang Zhu and Jie Gao

Journal of Neuroscience 31 July 2024, 44 (31) e0202242024; https://doi.org/10.1523/JNEUROSCI.0202-24.2024

Da Lin

1Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210

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Andrew Gold

2Department of Human Sciences, The Ohio State University, Columbus, Ohio 43210

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Sarah Kaye

1Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210

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Jeffrey R. Atkinson

3Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210

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Marcus Tol

4Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095

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Andrew Sas

3Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210

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Benjamin Segal

3Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210

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Peter Tontonoz

4Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095

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Jiangjiang Zhu

2Department of Human Sciences, The Ohio State University, Columbus, Ohio 43210

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Jie Gao

1Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210

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ORCID record for Jie Gao

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31 Jul 2024

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Arachidonic Acid Mobilization and Peroxidation Promote Microglial Dysfunction in Aβ Pathology

Da Lin, Andrew Gold, Sarah Kaye, Jeffrey R. Atkinson, Marcus Tol, Andrew Sas, Benjamin Segal, Peter Tontonoz, Jiangjiang Zhu, Jie Gao

Journal of Neuroscience 31 July 2024, 44 (31) e0202242024; DOI: 10.1523/JNEUROSCI.0202-24.2024

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Arachidonic Acid Mobilization and Peroxidation Promote Microglial Dysfunction in Aβ Pathology

Da Lin, Andrew Gold, Sarah Kaye, Jeffrey R. Atkinson, Marcus Tol, Andrew Sas, Benjamin Segal, Peter Tontonoz, Jiangjiang Zhu, Jie Gao

Journal of Neuroscience 31 July 2024, 44 (31) e0202242024; DOI: 10.1523/JNEUROSCI.0202-24.2024

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Keywords

Alzheimer's disease
arachidonic acid
lipid peroxidation
LPCAT3
microglial dysfunction
oxidative stress

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