A Virtual In Vivo Dissection and Analysis of Socioaffective Symptoms Related to Cerebellum-Midbrain Reward Circuitry in Humans

This research includes calculations carried out on HPC resources supported in part by the National Science Foundation through major research instrumentation grant number 1625061 and by the US Army Research Laboratory under contract number W911NF-16-2-0189. This work was supported by a National Institute of Health Grant to I.R.O. (R01 NICHD R01HD099165; R01 MH118545-01A1) and to H.S-T. (F32 MH127948-01A1). The content is solely the responsibility of the authors and does not represent the official views of the National Institute of Mental Health or the National Institutes of Health. Data were provided by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research and by the McDonnell Center for Systems Neuroscience at Washington University. We thank Drs. Volker Coenen, Marco Reisert, and Sascha du Lac for their insights into cerebello-midbrain connectivity and comments on the cerebellar connections to each DCN, respectively. We also thank Katie Jobson, Haroon Popal, and Vishnu Murty for contributing their knowledge of cerebellar and reward circuitry.