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Research Articles, Development/Plasticity/Repair

EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development

Hiroki Kagoshima, Hiroe Ohnishi, Ryosuke Yamamoto, Akiyoshi Yasumoto, Yosuke Tona, Takayuki Nakagawa, Koichi Omori and Norio Yamamoto
Journal of Neuroscience 14 February 2024, 44 (7) e1060232023; https://doi.org/10.1523/JNEUROSCI.1060-23.2023
Hiroki Kagoshima
1Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
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Hiroe Ohnishi
1Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
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  • ORCID record for Hiroe Ohnishi
Ryosuke Yamamoto
2Biological Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
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Akiyoshi Yasumoto
1Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
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Yosuke Tona
1Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
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Takayuki Nakagawa
1Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
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Koichi Omori
1Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
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Norio Yamamoto
1Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
3Department of Otolaryngology, Kobe City Medical Center General Hospital, Hyogo 650-0047, Japan
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1060-23.2023
PubMed 
38176908
Published By 
Society for Neuroscience
History 
  • Received June 7, 2023
  • Revision received November 12, 2023
  • Accepted December 13, 2023
  • First published January 4, 2024.
  • Version of record published February 14, 2024.
Copyright & Usage 
Copyright © 2024 the authors SfN exclusive license.

Author Information

  1. Hiroki Kagoshima1,
  2. Hiroe Ohnishi1,
  3. Ryosuke Yamamoto2,
  4. Akiyoshi Yasumoto1,
  5. Yosuke Tona1,
  6. Takayuki Nakagawa1,
  7. Koichi Omori1, and
  8. Norio Yamamoto1,3
  1. 1Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
  2. 2Biological Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
  3. 3Department of Otolaryngology, Kobe City Medical Center General Hospital, Hyogo 650-0047, Japan
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Author contributions

  1. Author contributions: H.O. and N.Y. designed research; H.K., H.O., R.Y., A.Y., Y.T., T.N., and K.O. performed research; H.K., A.Y., and N.Y. analyzed data; H.K. and N.Y. wrote the paper; H.K. and N.Y. wrote the first draft of the paper; N.Y. edited the paper.

Disclosures

    • Received June 7, 2023.
    • Revision received November 12, 2023.
    • Accepted December 13, 2023.
  • We thank Dr. Rudolf Grosschedl for providing Ebf1−/− and Ebf1fl/fl mice, Dr. Ryoichiro Kageyama for providing the Atoh1 ISH probe, and Center for Anatomical, Pathological and Forensic Medical Research, Graduate School of Medicine, Kyoto University for preparing hematoxylin–eosin staining slides. This study was supported by Japan Society for the Promotion of Science KAKENHI (grant number: JP22H03234) awarded to N.Y.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Norio Yamamoto at yamamoto{at}ent.kuhp.kyoto-u.ac.jp.

Funding

  • MEXT | Japan Society for the Promotion of Science (JSPS)

    JP22H03234

Other Version

  • previous version (January 04, 2024).
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The Journal of Neuroscience: 44 (7)
Journal of Neuroscience
Vol. 44, Issue 7
14 Feb 2024
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EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development
Hiroki Kagoshima, Hiroe Ohnishi, Ryosuke Yamamoto, Akiyoshi Yasumoto, Yosuke Tona, Takayuki Nakagawa, Koichi Omori, Norio Yamamoto
Journal of Neuroscience 14 February 2024, 44 (7) e1060232023; DOI: 10.1523/JNEUROSCI.1060-23.2023

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EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development
Hiroki Kagoshima, Hiroe Ohnishi, Ryosuke Yamamoto, Akiyoshi Yasumoto, Yosuke Tona, Takayuki Nakagawa, Koichi Omori, Norio Yamamoto
Journal of Neuroscience 14 February 2024, 44 (7) e1060232023; DOI: 10.1523/JNEUROSCI.1060-23.2023
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Keywords

  • early B-cell factor 1
  • hearing
  • inner ear prosensory domain
  • Kölliker’s organ
  • scala tympani
  • spiral limbus

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