This confocal image depicts mouse primary microglia that were exposed to alpha synuclein preformed fibrils to model Parkinson's disease. Microglial nuclei are labeled with Hoechst (grey), lysosomes and late endosomal compartments are labeled with LAMP1 (blue), and the protease cathepsin B is shown in orange. Strong induction of LAMP1 and cathepsin B protein levels promoted lysosomal integrity, enabling lysosomes to clear the toxic buildup of alpha synuclein. Exploring how microglia maintain lysosomal integrity is important for understanding the pathogenesis of Parkinson's disease. See the article by Karl E. Biggs et al. for information on the molecular mechanisms underlying the maintenance of microglial lysosomes. Cover image: Karl Biggs.