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Research Articles, Systems/Circuits

Neurons of the Central Nucleus of the Amygdala That Express Angiotensin Type 2 Receptors Couple Lowered Blood Pressure with Anxiolysis in Male Mice

Khalid Elsaafien, Matthew K. Kirchner, Karen A. Scott, Eliot A. Spector, Francesca E. Mowry, Colin Sumners, Javier E. Stern, Annette D. de Kloet and Eric G. Krause
Journal of Neuroscience 19 March 2025, 45 (12) e1482242025; https://doi.org/10.1523/JNEUROSCI.1482-24.2025
Khalid Elsaafien
1Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
2Center for Neuroinflammation and Cardiometabolic Diseases, College of Arts and Sciences Georgia State University, Atlanta, Georgia 30303
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Matthew K. Kirchner
1Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
2Center for Neuroinflammation and Cardiometabolic Diseases, College of Arts and Sciences Georgia State University, Atlanta, Georgia 30303
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Karen A. Scott
1Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
2Center for Neuroinflammation and Cardiometabolic Diseases, College of Arts and Sciences Georgia State University, Atlanta, Georgia 30303
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  • ORCID record for Karen A. Scott
Eliot A. Spector
3Departments of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610
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Francesca E. Mowry
1Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
2Center for Neuroinflammation and Cardiometabolic Diseases, College of Arts and Sciences Georgia State University, Atlanta, Georgia 30303
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Colin Sumners
4Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida 32610
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Javier E. Stern
1Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
2Center for Neuroinflammation and Cardiometabolic Diseases, College of Arts and Sciences Georgia State University, Atlanta, Georgia 30303
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Annette D. de Kloet
1Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
2Center for Neuroinflammation and Cardiometabolic Diseases, College of Arts and Sciences Georgia State University, Atlanta, Georgia 30303
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Eric G. Krause
1Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
2Center for Neuroinflammation and Cardiometabolic Diseases, College of Arts and Sciences Georgia State University, Atlanta, Georgia 30303
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1482-24.2025
PubMed 
39909561
Published By 
Society for Neuroscience
History 
  • Received August 5, 2024
  • Revision received January 10, 2025
  • Accepted January 15, 2025
  • First published February 5, 2025.
  • Version of record published March 19, 2025.
Copyright & Usage 
Copyright © 2025 the authors SfN exclusive license.

Author Information

  1. Khalid Elsaafien1,2,
  2. Matthew K. Kirchner1,2,
  3. Karen A. Scott1,2,
  4. Eliot A. Spector3,
  5. Francesca E. Mowry1,2,
  6. Colin Sumners4,
  7. Javier E. Stern1,2,
  8. Annette D. de Kloet1,2, and
  9. Eric G. Krause1,2
  1. 1Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303
  2. 2Center for Neuroinflammation and Cardiometabolic Diseases, College of Arts and Sciences Georgia State University, Atlanta, Georgia 30303
  3. 3Departments of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610
  4. 4Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida 32610
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Author contributions

  1. Author contributions: K.E., M.K.K., K.A.S., C.S., J.E.S., A.D.K., and E.G.K. designed research; K.E., M.K.K., K.A.S., E.A.S., F.E.M., J.E.S., A.D.K., and E.G.K. performed research; K.E., M.K.K., K.A.S., A.D.K., and E.G.K. contributed unpublished reagents/analytic tools; K.E., M.K.K., K.A.S., J.E.S., A.D.K., and E.G.K. analyzed data; K.E., M.K.K., K.A.S., J.E.S., A.D.K., and E.G.K. wrote the paper.

Disclosures

    • Received August 5, 2024.
    • Revision received January 10, 2025.
    • Accepted January 15, 2025.
  • This work was supported by the National Institutes of Health: R35HL150750 (E.G.K.), R01HL145028 (A.D.K.); AHA 23POST1020034 and K99HL175100 (K.E.).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Eric G. Krause at ekrause{at}gsu.edu or Annette D. de Kloet at adekloet{at}gsu.edu.

Funding

  • HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

    R35HL150750; R01HL145028; K99HL175100
  • American Heart Association (AHA)

    23POST1020034

Other Version

  • previous version (February 05, 2025).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 45 (12)
Journal of Neuroscience
Vol. 45, Issue 12
19 Mar 2025
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Neurons of the Central Nucleus of the Amygdala That Express Angiotensin Type 2 Receptors Couple Lowered Blood Pressure with Anxiolysis in Male Mice
Khalid Elsaafien, Matthew K. Kirchner, Karen A. Scott, Eliot A. Spector, Francesca E. Mowry, Colin Sumners, Javier E. Stern, Annette D. de Kloet, Eric G. Krause
Journal of Neuroscience 19 March 2025, 45 (12) e1482242025; DOI: 10.1523/JNEUROSCI.1482-24.2025

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Neurons of the Central Nucleus of the Amygdala That Express Angiotensin Type 2 Receptors Couple Lowered Blood Pressure with Anxiolysis in Male Mice
Khalid Elsaafien, Matthew K. Kirchner, Karen A. Scott, Eliot A. Spector, Francesca E. Mowry, Colin Sumners, Javier E. Stern, Annette D. de Kloet, Eric G. Krause
Journal of Neuroscience 19 March 2025, 45 (12) e1482242025; DOI: 10.1523/JNEUROSCI.1482-24.2025
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Keywords

  • affective
  • autonomic
  • depression
  • hypertension
  • meditation
  • stress

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