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Research Articles, Cellular/Molecular

The Serotonergic Dorsal Raphe Promotes Emergence from Propofol Anesthesia in Zebrafish

Xiaoxuan Yang, Shan Zhu, Miaoyun Xia, Le Sun, Sha Li, Peishan Xiang, Funing Li, Qiusui Deng, Lijun Chen, Wei Zhang, Ying Wang, Qiang Li, Zhuochen Lyu, Xufei Du, Jiulin Du, Qianzi Yang and Yan Luo
Journal of Neuroscience 9 April 2025, 45 (15) e2125232025; https://doi.org/10.1523/JNEUROSCI.2125-23.2025
Xiaoxuan Yang
1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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  • ORCID record for Xiaoxuan Yang
Shan Zhu
1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Miaoyun Xia
1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Le Sun
2Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
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Sha Li
2Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
3School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
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Peishan Xiang
2Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
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Funing Li
2Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
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Qiusui Deng
2Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
4University of Chinese Academy of Sciences, Beijing 100049, China
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Lijun Chen
2Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
3School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
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Wei Zhang
2Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
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Ying Wang
1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Qiang Li
1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Zhuochen Lyu
1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Xufei Du
2Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
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Jiulin Du
2Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
3School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
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Qianzi Yang
1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Yan Luo
1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2125-23.2025
PubMed 
39947921
Published By 
Society for Neuroscience
History 
  • Received November 7, 2023
  • Revision received December 30, 2024
  • Accepted January 27, 2025
  • First published February 13, 2025.
  • Version of record published April 9, 2025.
Copyright & Usage 
Copyright © 2025 the authors SfN exclusive license.

Author Information

  1. Xiaoxuan Yang1,*,
  2. Shan Zhu1,*,
  3. Miaoyun Xia1,*,
  4. Le Sun2,
  5. Sha Li2,3,
  6. Peishan Xiang2,
  7. Funing Li2,
  8. Qiusui Deng2,4,
  9. Lijun Chen2,3,
  10. Wei Zhang2,
  11. Ying Wang1,
  12. Qiang Li1,
  13. Zhuochen Lyu1,
  14. Xufei Du2,
  15. Jiulin Du2,3,
  16. Qianzi Yang1, and
  17. Yan Luo1
  1. 1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  2. 2Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
  3. 3School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
  4. 4University of Chinese Academy of Sciences, Beijing 100049, China
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Author contributions

  1. Author contributions: X.Y., J.D., Q.Y., and Y.L. designed research; X.Y., S.Z., L.S., S.L., P.X., and M.X. performed research; F.L., Q.D., L.C., W.Z., and X.D. contributed unpublished reagents/analytic tools; Q.L., Z.L., and Y.W. analyzed data; X.Y., Q.Y., and Y.L. wrote the paper.

Disclosures

    • Received November 7, 2023.
    • Revision received December 30, 2024.
    • Accepted January 27, 2025.
  • This work was supported by the National Natural Science Foundation of China (82001451 to X.Y., T2293734 and T2293730 to Y.L., 82271285 to Q.Y.). We appreciate Yongxin Yang for the expert assistance with the in vivo whole-cell recording technique and Changmei Zhang for the suggestions on writing the manuscript. All mentioned individuals are members of Jinlin Du's lab. We also thank Professor Zhe Zhang, Ph.D., from Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, for providing tetrodotoxin samples in electrophysiology experiment.

  • ↵*X.Y., S.Z., and M.X. contributed equally to this work.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Yan Luo at ly11087{at}rjh.com.cn or Qianzi Yang at qianziyang{at}hotmail.com.

Funding

  • MOST | National Natural Science Foundation of China (NSFC)

    82001451; T2293734 and T2293730; 82271285

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  • previous version (February 13, 2025).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 45 (15)
Journal of Neuroscience
Vol. 45, Issue 15
9 Apr 2025
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The Serotonergic Dorsal Raphe Promotes Emergence from Propofol Anesthesia in Zebrafish
Xiaoxuan Yang, Shan Zhu, Miaoyun Xia, Le Sun, Sha Li, Peishan Xiang, Funing Li, Qiusui Deng, Lijun Chen, Wei Zhang, Ying Wang, Qiang Li, Zhuochen Lyu, Xufei Du, Jiulin Du, Qianzi Yang, Yan Luo
Journal of Neuroscience 9 April 2025, 45 (15) e2125232025; DOI: 10.1523/JNEUROSCI.2125-23.2025

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The Serotonergic Dorsal Raphe Promotes Emergence from Propofol Anesthesia in Zebrafish
Xiaoxuan Yang, Shan Zhu, Miaoyun Xia, Le Sun, Sha Li, Peishan Xiang, Funing Li, Qiusui Deng, Lijun Chen, Wei Zhang, Ying Wang, Qiang Li, Zhuochen Lyu, Xufei Du, Jiulin Du, Qianzi Yang, Yan Luo
Journal of Neuroscience 9 April 2025, 45 (15) e2125232025; DOI: 10.1523/JNEUROSCI.2125-23.2025
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Keywords

  • 5-HT
  • dorsal raphe
  • general anesthesia
  • propofol
  • zebrafish

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