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Research Articles, Neurobiology of Disease

Hippocampal Neural Stem Cell Exosomes Promote Brain Resilience against the Impact of Tau Oligomers

Balaji Krishnan, Michela Marcatti, Anna Fracassi, Wen-Ru Zhang, Jutatip Guptarak, Kathia Johnson, Auston Grant, Rakez Kayed, Giulio Taglialatela and Maria-Adelaide Micci
Journal of Neuroscience 16 April 2025, 45 (16) e1664242025; https://doi.org/10.1523/JNEUROSCI.1664-24.2025
Balaji Krishnan
1Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555
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Michela Marcatti
1Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555
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Anna Fracassi
1Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555
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Wen-Ru Zhang
1Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555
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Jutatip Guptarak
1Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555
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Kathia Johnson
2Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555
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Auston Grant
2Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555
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Rakez Kayed
1Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555
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Giulio Taglialatela
1Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555
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Maria-Adelaide Micci
2Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1664-24.2025
PubMed 
40050115
Published By 
Society for Neuroscience
History 
  • Received September 27, 2024
  • Revision received December 20, 2024
  • Accepted January 28, 2025
  • First published March 6, 2025.
  • Version of record published April 16, 2025.
Copyright & Usage 
Copyright © 2025 the authors SfN exclusive license.

Author Information

  1. Balaji Krishnan1,
  2. Michela Marcatti1,
  3. Anna Fracassi1,
  4. Wen-Ru Zhang1,
  5. Jutatip Guptarak1,
  6. Kathia Johnson2,
  7. Auston Grant2,
  8. Rakez Kayed1,
  9. Giulio Taglialatela1,*, and
  10. Maria-Adelaide Micci2,*
  1. 1Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555
  2. 2Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555
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Author contributions

  1. Author contributions: B.K., R.K., G.T., and M.M. designed research; B.K., M.M., A.F., W.-R.Z., J.G., K.J., and A.G. performed research; R.K. contributed unpublished reagents/analytic tools; B.K., M.M., A.F., W.-R.Z., J.G., K.J., A.G., G.T., and M.-A.M. analyzed data; M.M. wrote the paper.

Disclosures

    • Received September 27, 2024.
    • Revision received December 20, 2024.
    • Accepted January 28, 2025.
  • This work was supported by NIA/NIH 5R01AG042890 (to M.-A.M. and G.T.). We thank Dr. Vsevolod L. Popov and Zhixia Ding for their helpful suggestions and for the use of the Department of Pathology EM facility and Stacy L. Sell, PhD, for editing.

  • ↵*G.T. and M.-A.M. contributed equally to this work.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Maria-Adelaide Micci at mmicci{at}utmb.edu or Giulio Taglialatela at gtaglial{at}utmb.edu.

Funding

  • NIH/NIA

    R01AG042890

Other Version

  • previous version (March 06, 2025).
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The Journal of Neuroscience: 45 (16)
Journal of Neuroscience
Vol. 45, Issue 16
16 Apr 2025
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Hippocampal Neural Stem Cell Exosomes Promote Brain Resilience against the Impact of Tau Oligomers
Balaji Krishnan, Michela Marcatti, Anna Fracassi, Wen-Ru Zhang, Jutatip Guptarak, Kathia Johnson, Auston Grant, Rakez Kayed, Giulio Taglialatela, Maria-Adelaide Micci
Journal of Neuroscience 16 April 2025, 45 (16) e1664242025; DOI: 10.1523/JNEUROSCI.1664-24.2025

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Hippocampal Neural Stem Cell Exosomes Promote Brain Resilience against the Impact of Tau Oligomers
Balaji Krishnan, Michela Marcatti, Anna Fracassi, Wen-Ru Zhang, Jutatip Guptarak, Kathia Johnson, Auston Grant, Rakez Kayed, Giulio Taglialatela, Maria-Adelaide Micci
Journal of Neuroscience 16 April 2025, 45 (16) e1664242025; DOI: 10.1523/JNEUROSCI.1664-24.2025
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Keywords

  • Alzheimer's disease
  • exosomes
  • neural stem cells
  • synapses
  • Tau oligomers
  • miRNAs

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