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Research Articles, Systems/Circuits

Spike Rate Inference from Mouse Spinal Cord Calcium Imaging Data

Peter Rupprecht, Wei Fan, Steve J. Sullivan, Fritjof Helmchen and Andrei D. Sdrulla
Journal of Neuroscience 30 April 2025, 45 (18) e1187242025; https://doi.org/10.1523/JNEUROSCI.1187-24.2025
Peter Rupprecht
1Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zurich, Zurich CH-8057, Switzerland
2Neuroscience Center Zurich, University of Zurich, Zurich CH-8057, Switzerland
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Wei Fan
3Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239-3098
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Steve J. Sullivan
3Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239-3098
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Fritjof Helmchen
1Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zurich, Zurich CH-8057, Switzerland
2Neuroscience Center Zurich, University of Zurich, Zurich CH-8057, Switzerland
4University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning, University of Zurich, Zurich CH-8057, Switzerland
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Andrei D. Sdrulla
3Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239-3098
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1187-24.2025
PubMed 
40127941
Published By 
Society for Neuroscience
History 
  • Received June 15, 2024
  • Revision received March 5, 2025
  • Accepted March 14, 2025
  • First published March 24, 2025.
  • Version of record published April 30, 2025.
Copyright & Usage 
Copyright © 2025 Rupprecht et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Peter Rupprecht1,2,
  2. Wei Fan3,
  3. Steve J. Sullivan3,
  4. Fritjof Helmchen1,2,4, and
  5. Andrei D. Sdrulla3
  1. 1Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zurich, Zurich CH-8057, Switzerland
  2. 2Neuroscience Center Zurich, University of Zurich, Zurich CH-8057, Switzerland
  3. 3Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239-3098
  4. 4University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning, University of Zurich, Zurich CH-8057, Switzerland
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Author contributions

  1. Author contributions: P.R., F.H., and A.D.S. designed research; P.R., W.F., S.J.S., and A.D.S. performed research; P.R. and A.D.S. contributed unpublished reagents/analytic tools; P.R. analyzed data; P.R., S.J.S., F.H., and A.D.S. wrote the paper.

Disclosures

    • Received June 15, 2024.
    • Revision received March 5, 2025.
    • Accepted March 14, 2025.
  • This work was supported by the National Institutes of Health (grants K08NS099503, RF1NS124557 to A.D.S.) and by grants from the Swiss National Science Foundation (project grant 310030B_170269 to F.H.; Ambizione grant PZ00P3_209114 to P.R.). This project was supported by the OHSU Advanced Light Microscopy (RRID: SCR_009961) core.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Peter Rupprecht at rupprecht{at}hifo.uzh.ch or Andrei D. Sdrulla at sdrulla{at}ohsu.edu.

Funding

  • HHS | National Institutes of Health (NIH)

    K08NS099503; RF1NS124557
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF)

    PZ00P3_209114; 310030B_170269

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  • previous version (March 24, 2025).
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The Journal of Neuroscience: 45 (18)
Journal of Neuroscience
Vol. 45, Issue 18
30 Apr 2025
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Spike Rate Inference from Mouse Spinal Cord Calcium Imaging Data
Peter Rupprecht, Wei Fan, Steve J. Sullivan, Fritjof Helmchen, Andrei D. Sdrulla
Journal of Neuroscience 30 April 2025, 45 (18) e1187242025; DOI: 10.1523/JNEUROSCI.1187-24.2025

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Spike Rate Inference from Mouse Spinal Cord Calcium Imaging Data
Peter Rupprecht, Wei Fan, Steve J. Sullivan, Fritjof Helmchen, Andrei D. Sdrulla
Journal of Neuroscience 30 April 2025, 45 (18) e1187242025; DOI: 10.1523/JNEUROSCI.1187-24.2025
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Keywords

  • calcium imaging
  • cell-attached
  • deconvolution
  • deep learning
  • spike inference
  • spinal cord

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