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Cover ArticleResearch Articles, Systems/Circuits

CCKergic Tufted Cells Regulate Odor Sensitivity by Controlling Mitral Cell Output in the Mouse Olfactory Bulb

Eric Starr, Rashika Budhathoki, Dylan Gilhooly, Laura Castillo, Meigeng Hu, Dan Zhao, Yaping Li and Shaolin Liu
Journal of Neuroscience 30 April 2025, 45 (18) e1243242025; https://doi.org/10.1523/JNEUROSCI.1243-24.2025
Eric Starr
1Department of Anatomy, Howard University, Washington, DC 20059
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Rashika Budhathoki
1Department of Anatomy, Howard University, Washington, DC 20059
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Dylan Gilhooly
1Department of Anatomy, Howard University, Washington, DC 20059
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Laura Castillo
1Department of Anatomy, Howard University, Washington, DC 20059
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Meigeng Hu
2Center for Neurological Disease Research, Departments of Physiology and Pharmacology and Biomedical Sciences, University of Georgia College of Veterinary Medicine, Athens, Georgia 30602
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Dan Zhao
2Center for Neurological Disease Research, Departments of Physiology and Pharmacology and Biomedical Sciences, University of Georgia College of Veterinary Medicine, Athens, Georgia 30602
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Yaping Li
2Center for Neurological Disease Research, Departments of Physiology and Pharmacology and Biomedical Sciences, University of Georgia College of Veterinary Medicine, Athens, Georgia 30602
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Shaolin Liu
1Department of Anatomy, Howard University, Washington, DC 20059
2Center for Neurological Disease Research, Departments of Physiology and Pharmacology and Biomedical Sciences, University of Georgia College of Veterinary Medicine, Athens, Georgia 30602
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1243-24.2025
PubMed 
40127939
Published By 
Society for Neuroscience
History 
  • Received June 22, 2024
  • Revision received February 11, 2025
  • Accepted March 3, 2025
  • First published March 24, 2025.
  • Version of record published April 30, 2025.
Copyright & Usage 
Copyright © 2025 Starr et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Eric Starr1,
  2. Rashika Budhathoki1,
  3. Dylan Gilhooly1,
  4. Laura Castillo1,
  5. Meigeng Hu2,
  6. Dan Zhao2,
  7. Yaping Li2, and
  8. Shaolin Liu1,2
  1. 1Department of Anatomy, Howard University, Washington, DC 20059
  2. 2Center for Neurological Disease Research, Departments of Physiology and Pharmacology and Biomedical Sciences, University of Georgia College of Veterinary Medicine, Athens, Georgia 30602
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Author contributions

  1. Author contributions: S.L. designed research; E.S., R.B., D.G., L.C., M.H., D.Z., Y.L., and S.L. performed research; E.S., R.B., L.C., and S.L. analyzed data; E.S. and S.L. wrote the paper.

Disclosures

    • Received June 22, 2024.
    • Revision received February 11, 2025.
    • Accepted March 3, 2025.
  • We thank Corinne A. Perloski for her assistance in animal care and maintenance. This work was supported by NIH Grants R01DC014447, RF1AG069196, R01AG074216, and R01AG077541.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Shaolin Liu at shaolin.liu{at}uga.edu.

Funding

  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    R01DC14447
  • HHS | NIH | National Institute on Aging (NIA)

    RF1AG069196; R01AG074216; R01AG077541

Other Version

  • previous version (March 24, 2025).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 45 (18)
Journal of Neuroscience
Vol. 45, Issue 18
30 Apr 2025
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CCKergic Tufted Cells Regulate Odor Sensitivity by Controlling Mitral Cell Output in the Mouse Olfactory Bulb
Eric Starr, Rashika Budhathoki, Dylan Gilhooly, Laura Castillo, Meigeng Hu, Dan Zhao, Yaping Li, Shaolin Liu
Journal of Neuroscience 30 April 2025, 45 (18) e1243242025; DOI: 10.1523/JNEUROSCI.1243-24.2025

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CCKergic Tufted Cells Regulate Odor Sensitivity by Controlling Mitral Cell Output in the Mouse Olfactory Bulb
Eric Starr, Rashika Budhathoki, Dylan Gilhooly, Laura Castillo, Meigeng Hu, Dan Zhao, Yaping Li, Shaolin Liu
Journal of Neuroscience 30 April 2025, 45 (18) e1243242025; DOI: 10.1523/JNEUROSCI.1243-24.2025
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Keywords

  • gap junction
  • mitral cell
  • neural circuits
  • odor detection
  • olfactory bulb
  • synaptic transmission

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