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Research Articles, Cellular/Molecular

Activational and Organizational Effects of Sex Hormones on Hippocampal Inhibitory Neurons

Alicia Hernández-Vivanco, Rut de la Vega-Ruiz, Alberto Montes-Mellado, Íñigo Azcoitia and Pablo Méndez
Journal of Neuroscience 30 April 2025, 45 (18) e1764242025; https://doi.org/10.1523/JNEUROSCI.1764-24.2025
Alicia Hernández-Vivanco
1Instituto Cajal (CSIC), Madrid 28002, Spain
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Rut de la Vega-Ruiz
1Instituto Cajal (CSIC), Madrid 28002, Spain
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Alberto Montes-Mellado
1Instituto Cajal (CSIC), Madrid 28002, Spain
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Íñigo Azcoitia
2Department of Cell Biology, Universidad Complutense de Madrid, Madrid 28040, Spain
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Pablo Méndez
1Instituto Cajal (CSIC), Madrid 28002, Spain
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1764-24.2025
PubMed 
40097180
Published By 
Society for Neuroscience
History 
  • Received September 17, 2024
  • Revision received February 12, 2025
  • Accepted February 16, 2025
  • First published March 17, 2025.
  • Version of record published April 30, 2025.
Copyright & Usage 
Copyright © 2025 the authors SfN exclusive license.

Author Information

  1. Alicia Hernández-Vivanco1,
  2. Rut de la Vega-Ruiz1,
  3. Alberto Montes-Mellado1,
  4. Íñigo Azcoitia2, and
  5. Pablo Méndez1
  1. 1Instituto Cajal (CSIC), Madrid 28002, Spain
  2. 2Department of Cell Biology, Universidad Complutense de Madrid, Madrid 28040, Spain
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Author contributions

  1. Author contributions: P.M. designed research; A.H-V., R.D.L.V-R., A.M-M., I.A., and P.M. performed research; A.H-V., R.D.L.V-R., A.M-M., and I.A. analyzed data; P.M. wrote the paper.

Disclosures

    • Received September 17, 2024.
    • Revision received February 12, 2025.
    • Accepted February 16, 2025.
  • This work was supported by grants PID2020-112428GB-I00 and PID2023-147398NB-I00 by MICIU/AEI/10.13039/501100011033 to P.M. A.M-M is supported by a JAEIntro scholarship funded by CSIC. R.D.L.V-R. is supported by the Ph.D. fellowship PRE2021-099806 funded by MICIU/AEI/10.13039/501100011033 by “ESF Investing in your future.” We thank Beatriz Rico (King’s College, London, UK) for providing the plasmids used to generate the aromatase gene knockdown.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Pablo Méndez at pmendez{at}cajal.csic.es.

Funding

  • Ministerio de Ciencia e Innovación (MCIN)

    PID2020-112428GB-I00; PRE2021-099806; PID2023-147398NB-I00

Other Version

  • previous version (March 17, 2025).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 45 (18)
Journal of Neuroscience
Vol. 45, Issue 18
30 Apr 2025
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Activational and Organizational Effects of Sex Hormones on Hippocampal Inhibitory Neurons
Alicia Hernández-Vivanco, Rut de la Vega-Ruiz, Alberto Montes-Mellado, Íñigo Azcoitia, Pablo Méndez
Journal of Neuroscience 30 April 2025, 45 (18) e1764242025; DOI: 10.1523/JNEUROSCI.1764-24.2025

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Activational and Organizational Effects of Sex Hormones on Hippocampal Inhibitory Neurons
Alicia Hernández-Vivanco, Rut de la Vega-Ruiz, Alberto Montes-Mellado, Íñigo Azcoitia, Pablo Méndez
Journal of Neuroscience 30 April 2025, 45 (18) e1764242025; DOI: 10.1523/JNEUROSCI.1764-24.2025
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Keywords

  • estrogen
  • hippocampus
  • inhibitory neuron
  • sex differences
  • testosterone

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