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Research Articles, Development/Plasticity/Repair

Acoustic Enrichment Prevents Early Life Stress-Induced Disruptions in Sound Azimuth Processing

Pengying An, Yue Fang, Yuan Cheng, Hui Liu, Wenjing Yang, Ye Shan, Etienne de Villers-Sidani, Guimin Zhang and Xiaoming Zhou
Journal of Neuroscience 30 April 2025, 45 (18) e2287242025; https://doi.org/10.1523/JNEUROSCI.2287-24.2025
Pengying An
1Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai 200062, China
2New York University-East China Normal University (NYU-ECNU) Institute of Brain and Cognitive Science, NYU-Shanghai, Shanghai 200062, China
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Yue Fang
1Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai 200062, China
2New York University-East China Normal University (NYU-ECNU) Institute of Brain and Cognitive Science, NYU-Shanghai, Shanghai 200062, China
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Yuan Cheng
1Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai 200062, China
2New York University-East China Normal University (NYU-ECNU) Institute of Brain and Cognitive Science, NYU-Shanghai, Shanghai 200062, China
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Hui Liu
1Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai 200062, China
2New York University-East China Normal University (NYU-ECNU) Institute of Brain and Cognitive Science, NYU-Shanghai, Shanghai 200062, China
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Wenjing Yang
1Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai 200062, China
2New York University-East China Normal University (NYU-ECNU) Institute of Brain and Cognitive Science, NYU-Shanghai, Shanghai 200062, China
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Ye Shan
1Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai 200062, China
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Etienne de Villers-Sidani
3Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
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  • ORCID record for Etienne de Villers-Sidani
Guimin Zhang
1Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai 200062, China
2New York University-East China Normal University (NYU-ECNU) Institute of Brain and Cognitive Science, NYU-Shanghai, Shanghai 200062, China
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Xiaoming Zhou
1Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai 200062, China
2New York University-East China Normal University (NYU-ECNU) Institute of Brain and Cognitive Science, NYU-Shanghai, Shanghai 200062, China
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2287-24.2025
PubMed 
40127935
Published By 
Society for Neuroscience
History 
  • Received December 3, 2024
  • Revision received February 19, 2025
  • Accepted March 15, 2025
  • First published March 24, 2025.
  • Version of record published April 30, 2025.
Copyright & Usage 
Copyright © 2025 the authors SfN exclusive license.

Author Information

  1. Pengying An1,2,*,
  2. Yue Fang1,2,*,
  3. Yuan Cheng1,2,
  4. Hui Liu1,2,
  5. Wenjing Yang1,2,
  6. Ye Shan1,
  7. Etienne de Villers-Sidani3,
  8. Guimin Zhang1,2, and
  9. Xiaoming Zhou1,2
  1. 1Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai 200062, China
  2. 2New York University-East China Normal University (NYU-ECNU) Institute of Brain and Cognitive Science, NYU-Shanghai, Shanghai 200062, China
  3. 3Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
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Author contributions

  1. Author contributions: G.Z. and X.Z. designed research; P.A., Y.F., Y.C., H.L., W.Y., Y.S., and G.Z. performed research; P.A., Y.F., Y.C., H.L., W.Y., Y.S., E.d.V.-S., and G.Z. analyzed data; X.Z. wrote the paper.

Disclosures

    • Received December 3, 2024.
    • Revision received February 19, 2025.
    • Accepted March 15, 2025.
  • We thank Christoph Schreiner, Jufang He, and Robert Froemke for their helpful discussions on earlier versions of this paper. X.Z. receives funding from the National Science and Technology Innovation 2030 Major Program (2022ZD0204804), the National Natural Science Foundation of China (32161160325, 32171134, 32471059), the Joint Fund for Medicine and Health from the ECNU (2022JKXYD08001), and the matching fund from the NYU-ECNU Institute of Brain and Cognitive Science at the NYU Shanghai.

  • ↵*P.A. and Y.F. contributed equally to this work.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Guimin Zhang at gmzhang{at}bio.ecnu.edu.cn or Xiaoming Zhou at xmzhou{at}bio.ecnu.edu.cn.

Funding

  • National Science and Technology Major Project (国家科技重大专项)

    2022ZD0204804
  • MOST | National Natural Science Foundation of China (NSFC)

    32161160325; 32171134

Other Version

  • previous version (March 24, 2025).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 45 (18)
Journal of Neuroscience
Vol. 45, Issue 18
30 Apr 2025
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Acoustic Enrichment Prevents Early Life Stress-Induced Disruptions in Sound Azimuth Processing
Pengying An, Yue Fang, Yuan Cheng, Hui Liu, Wenjing Yang, Ye Shan, Etienne de Villers-Sidani, Guimin Zhang, Xiaoming Zhou
Journal of Neuroscience 30 April 2025, 45 (18) e2287242025; DOI: 10.1523/JNEUROSCI.2287-24.2025

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Acoustic Enrichment Prevents Early Life Stress-Induced Disruptions in Sound Azimuth Processing
Pengying An, Yue Fang, Yuan Cheng, Hui Liu, Wenjing Yang, Ye Shan, Etienne de Villers-Sidani, Guimin Zhang, Xiaoming Zhou
Journal of Neuroscience 30 April 2025, 45 (18) e2287242025; DOI: 10.1523/JNEUROSCI.2287-24.2025
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Keywords

  • acoustic enrichment
  • auditory cortex
  • behavioral discrimination
  • cortical processing
  • early life stress

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