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Research Articles, Behavioral/Cognitive

Functional Heterogeneity within the Primate Ventral Striatum for Motivational Regulation

Haruhiko Iwaoki, Yukiko Hori, Yuki Hori, Koki Mimura, Kei Oyama, Yuji Nagai, Toshiyuki Hirabayashi, Ken-ichi Inoue, Masahiko Takada, Makoto Higuchi and Takafumi Minamimoto
Journal of Neuroscience 21 May 2025, 45 (21) e2430242025; https://doi.org/10.1523/JNEUROSCI.2430-24.2025
Haruhiko Iwaoki
1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
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Yukiko Hori
1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
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Yuki Hori
1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
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Koki Mimura
1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
2National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan
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Kei Oyama
1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
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Yuji Nagai
1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
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Toshiyuki Hirabayashi
1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
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Ken-ichi Inoue
3Systems Neuroscience Section, Center for the Evolutionary Origins of Human Behavior, Kyoto University, Aichi 484-8506, Japan
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Masahiko Takada
3Systems Neuroscience Section, Center for the Evolutionary Origins of Human Behavior, Kyoto University, Aichi 484-8506, Japan
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  • ORCID record for Masahiko Takada
Makoto Higuchi
1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
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Takafumi Minamimoto
1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
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  • ORCID record for Takafumi Minamimoto
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2430-24.2025
PubMed 
40228898
Published By 
Society for Neuroscience
History 
  • Received December 23, 2024
  • Revision received April 2, 2025
  • Accepted April 7, 2025
  • First published April 14, 2025.
  • Version of record published May 21, 2025.
Copyright & Usage 
Copyright © 2025 Iwaoki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Haruhiko Iwaoki1,
  2. Yukiko Hori1,
  3. Yuki Hori1,
  4. Koki Mimura1,2,
  5. Kei Oyama1,
  6. Yuji Nagai1,
  7. Toshiyuki Hirabayashi1,
  8. Ken-ichi Inoue3,
  9. Masahiko Takada3,
  10. Makoto Higuchi1, and
  11. Takafumi Minamimoto1
  1. 1Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
  2. 2National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan
  3. 3Systems Neuroscience Section, Center for the Evolutionary Origins of Human Behavior, Kyoto University, Aichi 484-8506, Japan
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Author contributions

  1. Author contributions: H.I., Yukiko Hori, and T.M. designed research; H.I., Yukiko Hori, Y.N., K.I., and T.M. performed research; H.I., Yukiko Hori, K.M., and T.M. analyzed data; H.I., Yukiko Hori, Yuki Hori, K.M., K.O., Y.N., T.H., K.I., M.T., M.H., and T.M. wrote the paper.

Disclosures

    • Received December 23, 2024.
    • Revision received April 2, 2025.
    • Accepted April 7, 2025.
  • This research was supported by MEXT/JSPS KAKENHI Grant Numbers JP20H05955, JP24H00069 (to T.M.), 24H00734 (to T.H.), 22H05157 (to K.I.), and JP23K12943 (to H.I.), by AMED Grant JP23wm0625001 (to T.M.), JP24wm0625307 (to T.H.), and by JST ACT-X Grant Number JPMJAX24C4 (to H.I.). We thank Erika Kikuchi, Jun Kamei, Yuichi Matsuda, Ryuji Yamaguchi, Yoshio Sugii, and Rie Yoshida for their technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Takafumi Minamimoto at minamimoto.takafumi{at}qst.go.jp.

Funding

  • MEXT | Japan Society for the Promotion of Science (JSPS)

    JP20H05955; 24H00734; 22H05157; JP23K12943
  • Japan Agency for Medical Research and Development (AMED)

    JP24wm0625307
  • MEXT | JST | ACT-X

    JPMJAX24C4

Other Version

  • previous version (April 14, 2025).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 45 (21)
Journal of Neuroscience
Vol. 45, Issue 21
21 May 2025
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Functional Heterogeneity within the Primate Ventral Striatum for Motivational Regulation
Haruhiko Iwaoki, Yukiko Hori, Yuki Hori, Koki Mimura, Kei Oyama, Yuji Nagai, Toshiyuki Hirabayashi, Ken-ichi Inoue, Masahiko Takada, Makoto Higuchi, Takafumi Minamimoto
Journal of Neuroscience 21 May 2025, 45 (21) e2430242025; DOI: 10.1523/JNEUROSCI.2430-24.2025

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Functional Heterogeneity within the Primate Ventral Striatum for Motivational Regulation
Haruhiko Iwaoki, Yukiko Hori, Yuki Hori, Koki Mimura, Kei Oyama, Yuji Nagai, Toshiyuki Hirabayashi, Ken-ichi Inoue, Masahiko Takada, Makoto Higuchi, Takafumi Minamimoto
Journal of Neuroscience 21 May 2025, 45 (21) e2430242025; DOI: 10.1523/JNEUROSCI.2430-24.2025
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Keywords

  • checking
  • monkey
  • motivation
  • muscimol
  • resting
  • ventral striatum

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