Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
Research Articles, Systems/Circuits

Infralimbic Projections to the Substantia Innominata–Ventral Pallidum Constrain Defensive Behavior during Extinction Learning

Carolina Fernandes-Henriques, Yuval Guetta, Mia G. Sclar, Rebecca Zhang, Yuka Miura, Katherine R. Surrence, Allyson K. Friedman and Ekaterina Likhtik
Journal of Neuroscience 28 May 2025, 45 (22) e1001242025; https://doi.org/10.1523/JNEUROSCI.1001-24.2025
Carolina Fernandes-Henriques
1Biology Program, The Graduate Center, CUNY, New York 10016
2Departments of Biological Sciences, Hunter College, CUNY, New York 10065
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuval Guetta
3Psychology, Hunter College, CUNY, New York 10065
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yuval Guetta
Mia G. Sclar
2Departments of Biological Sciences, Hunter College, CUNY, New York 10065
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Mia G. Sclar
Rebecca Zhang
2Departments of Biological Sciences, Hunter College, CUNY, New York 10065
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuka Miura
1Biology Program, The Graduate Center, CUNY, New York 10016
2Departments of Biological Sciences, Hunter College, CUNY, New York 10065
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katherine R. Surrence
2Departments of Biological Sciences, Hunter College, CUNY, New York 10065
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Allyson K. Friedman
1Biology Program, The Graduate Center, CUNY, New York 10016
2Departments of Biological Sciences, Hunter College, CUNY, New York 10065
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ekaterina Likhtik
1Biology Program, The Graduate Center, CUNY, New York 10016
2Departments of Biological Sciences, Hunter College, CUNY, New York 10065
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ekaterina Likhtik
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • Peer Review
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1001-24.2025
PubMed 
40262898
Published By 
Society for Neuroscience
History 
  • Received May 23, 2024
  • Revision received April 3, 2025
  • Accepted April 7, 2025
  • First published April 22, 2025.
  • Version of record published May 28, 2025.
Copyright & Usage 
Copyright © 2025 the authors SfN exclusive license.

Author Information

  1. Carolina Fernandes-Henriques1,2,*,
  2. Yuval Guetta3,*,
  3. Mia G. Sclar2,*,
  4. Rebecca Zhang2,
  5. Yuka Miura1,2,
  6. Katherine R. Surrence2,
  7. Allyson K. Friedman1,2, and
  8. Ekaterina Likhtik1,2
  1. 1Biology Program, The Graduate Center, CUNY, New York 10016
  2. 2Departments of Biological Sciences, Hunter College, CUNY, New York 10065
  3. 3Psychology, Hunter College, CUNY, New York 10065
View Full Text

Author contributions

  1. Author contributions: C.F.-H., A.K.F., and E.L. designed research; C.F.-H., Y.G., M.G.S., Y.M., and A.K.F. performed research; R.Z. contributed unpublished reagents/analytic tools; C.F.-H., Y.G., M.G.S., K.R.S., and E.L. analyzed data; E.L. wrote the paper.

Disclosures

    • Received May 23, 2024.
    • Revision received April 3, 2025.
    • Accepted April 7, 2025.
  • This work was supported by a National Institutes of Health Research Program Grant (MH118441). We thank Dr. Sarah Mennenga for her help with statistical modeling, Dr. Andrew Delamater for his helpful discussions of the manuscript, and Itzick Nahmoud for his help with programming of the behavioral equipment.

  • ↵*C.F.-H., Y.G., and M.G.S. contributed equally to this work.

  • Dedication: We dedicate this work to Dr. Carolina Fernandes-Henriques who passed away in August 2024. Her creativity and spirit have made this work possible, and she will be missed.

  • The authors declare no competing financial interests.

  • This paper contains supplemental material available at: https://doi.org/10.1523/JNEUROSCI.1001-24.2025

  • Correspondence should be addressed to Ekaterina Likhtik at elikhtik{at}genectr.hunter.cuny.edu.

Funding

  • National Institutes of Mental Health

    MH118441

Other Version

  • previous version (April 22, 2025).
  • You are viewing the most recent version of this article.

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-06-16
to
E.g., 2025-06-16

Article usage: April 2025 to June 2025

AbstractFullPdf
Apr 2025581050
May 20257704557
Jun 20252542416
Total 2025160569123
Total160569123
Back to top

In this issue

The Journal of Neuroscience: 45 (22)
Journal of Neuroscience
Vol. 45, Issue 22
28 May 2025
  • Table of Contents
  • About the Cover
  • Index by author
  • Masthead (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Infralimbic Projections to the Substantia Innominata–Ventral Pallidum Constrain Defensive Behavior during Extinction Learning
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Infralimbic Projections to the Substantia Innominata–Ventral Pallidum Constrain Defensive Behavior during Extinction Learning
Carolina Fernandes-Henriques, Yuval Guetta, Mia G. Sclar, Rebecca Zhang, Yuka Miura, Katherine R. Surrence, Allyson K. Friedman, Ekaterina Likhtik
Journal of Neuroscience 28 May 2025, 45 (22) e1001242025; DOI: 10.1523/JNEUROSCI.1001-24.2025

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Infralimbic Projections to the Substantia Innominata–Ventral Pallidum Constrain Defensive Behavior during Extinction Learning
Carolina Fernandes-Henriques, Yuval Guetta, Mia G. Sclar, Rebecca Zhang, Yuka Miura, Katherine R. Surrence, Allyson K. Friedman, Ekaterina Likhtik
Journal of Neuroscience 28 May 2025, 45 (22) e1001242025; DOI: 10.1523/JNEUROSCI.1001-24.2025
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • Peer Review
  • PDF

Keywords

  • amygdala
  • fear extinction
  • infralimbic
  • learning
  • substantia innominata
  • ventral pallidum

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Articles

  • Change of spiny neuron structure in the basal ganglia song circuit and its regulation by miR-9 during song development
  • Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer’s Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration.
  • Presynaptic mu opioid receptors suppress the functional connectivity of ventral tegmental area dopaminergic neurons with aversion-related brain regions
Show more Research Articles

Systems/Circuits

  • Presynaptic mu opioid receptors suppress the functional connectivity of ventral tegmental area dopaminergic neurons with aversion-related brain regions
  • V2b neurons act via multiple targets to produce in phase inhibition during locomotion
  • Specializations in Amygdalar and Hippocampal Innervation of the Primate Nucleus Accumbens Shell
Show more Systems/Circuits
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.