Sequence Diversity and Encoded Enzymatic Differences of Monocistronic L1 ORF2 mRNA Variants in the Aged Normal and Alzheimer's Disease Brain

Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health (NIH) under Awards R01 AG065541 and NIH R01 AG071465 and by nonfederal funds from The Bruce Ford & Anne Smith Bundy Foundation and the Larry L. Hillblom Foundation (J.C.) and NIH T32 GM007198-42S1 and R01 AG065541-02/03S1 (J.N.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Brain specimens were obtained from Dalhousie, Goizueta Alzheimer's Disease Research Center at Emory University, NIH Neurobiobank (Sepulveda), Southwest Dementia Brain Bank, University of California San Diego ADRC, and Washington University. We also thank the donors and families who shared these precious brain materials. We thank Danielle Jones; Nicole Coufal, MD PhD; and Carter Palmer, PhD, for their discussions and input; Laura Wolszon, PhD, for her efforts to source and obtain human specimens; and Kang Liu, PhD, at the Sanford Burnham Prebys Medical Discovery Institute Genomics Core for the RIN analysis of brain samples.

J.C. has an employment relationship with Neurocrine Biosciences, a company that may potentially benefit from the research results. J.C.’s relationship with Neurocrine Biosciences has been reviewed and approved by Sanford Burnham Prebys Medical Discovery Institute in accordance with its Conflict of Interest Policies.