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Featured ArticleResearch Articles, Systems/Circuits

Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking

Valentina Martinez Damonte, Lydia G. Bailey, Amit Thakar, Joanna Stralka, Travis E. Brown and Julie A. Kauer
Journal of Neuroscience 22 October 2025, 45 (43) e1233252025; https://doi.org/10.1523/JNEUROSCI.1233-25.2025
Valentina Martinez Damonte
1Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California 94305
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Lydia G. Bailey
2Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99163
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Amit Thakar
2Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99163
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Joanna Stralka
1Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California 94305
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Travis E. Brown
2Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99163
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Julie A. Kauer
1Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California 94305
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1233-25.2025
PubMed 
40954032
Published By 
Society for Neuroscience
History 
  • Received June 23, 2025
  • Revision received August 22, 2025
  • Accepted August 31, 2025
  • First published September 15, 2025.
  • Version of record published October 22, 2025.
Copyright & Usage 
Copyright © 2025 the authors SfN exclusive license.

Author Information

  1. Valentina Martinez Damonte1,*,
  2. Lydia G. Bailey2,*,
  3. Amit Thakar2,
  4. Joanna Stralka1,
  5. Travis E. Brown2, and
  6. Julie A. Kauer1
  1. 1Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California 94305
  2. 2Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99163
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Author contributions

  1. Author contributions: V.M.D., L.G.B., T.E.B., and J.A.K. designed research; V.M.D., L.G.B., A.T., and J.S. performed research; V.M.D., L.G.B., A.T., J.S., T.E.B., and J.A.K. analyzed data; V.M.D., L.G.B., T.E.B., and J.A.K. wrote the paper.

Disclosures

    • Received June 23, 2025.
    • Revision received August 22, 2025.
    • Accepted August 31, 2025.
  • We thank Dr. Chelsie Brewer for her technical and scientific contributions and Caroline Casper, Junhong Li, and Annie Wolfden for their technical assistance. This work was supported by National Institutes of Health (NIH) R01 DA 011289 to J.A.K. and T.E.B., R01 DA 055645 to T.E.B., Stanford University Dean’s Award (V.M.D.), and Washington State University Alcohol and Drug Abuse Research Program (L.G.B.).

  • ↵*V.M.D. and L.G.B contributed equally to this work.

  • The authors declare no competing financial interests.

  • This paper contains supplemental material available at: https://doi.org/10.1523/JNEUROSCI.1233-25.2025

  • Correspondence should be addressed to Julie A. Kauer at jkauer{at}stanford.edu.

Funding

  • HHS | National Institutes of Health (NIH)

    R01 DA 011289; R01 DA 055645

Other Version

  • previous version (September 15, 2025).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 45 (43)
Journal of Neuroscience
Vol. 45, Issue 43
22 Oct 2025
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Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking
Valentina Martinez Damonte, Lydia G. Bailey, Amit Thakar, Joanna Stralka, Travis E. Brown, Julie A. Kauer
Journal of Neuroscience 22 October 2025, 45 (43) e1233252025; DOI: 10.1523/JNEUROSCI.1233-25.2025

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Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking
Valentina Martinez Damonte, Lydia G. Bailey, Amit Thakar, Joanna Stralka, Travis E. Brown, Julie A. Kauer
Journal of Neuroscience 22 October 2025, 45 (43) e1233252025; DOI: 10.1523/JNEUROSCI.1233-25.2025
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Keywords

  • LTP
  • nucleus accumbens
  • optogenetics
  • plasticity
  • self-administration
  • ventral tegmental area

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