Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking

Valentina Martinez Damonte; Lydia G. Bailey; Amit Thakar; Joanna Stralka; Travis E. Brown; Julie A. Kauer

doi:10.1523/JNEUROSCI.1233-25.2025

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Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking

Valentina Martinez Damonte, Lydia G. Bailey, Amit Thakar, Joanna Stralka, Travis E. Brown and Julie A. Kauer

Journal of Neuroscience 22 October 2025, 45 (43) e1233252025; https://doi.org/10.1523/JNEUROSCI.1233-25.2025

Valentina Martinez Damonte

1Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California 94305

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Lydia G. Bailey

2Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99163

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Amit Thakar

2Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99163

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Joanna Stralka

1Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California 94305

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Travis E. Brown

2Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99163

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Julie A. Kauer

1Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California 94305

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Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking

Valentina Martinez Damonte, Lydia G. Bailey, Amit Thakar, Joanna Stralka, Travis E. Brown, Julie A. Kauer

Journal of Neuroscience 22 October 2025, 45 (43) e1233252025; DOI: 10.1523/JNEUROSCI.1233-25.2025

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Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking

Valentina Martinez Damonte, Lydia G. Bailey, Amit Thakar, Joanna Stralka, Travis E. Brown, Julie A. Kauer

Journal of Neuroscience 22 October 2025, 45 (43) e1233252025; DOI: 10.1523/JNEUROSCI.1233-25.2025

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LTP
nucleus accumbens
optogenetics
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ventral tegmental area

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