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Research Articles, Cellular/Molecular

Synaptic Properties of Layer 6 Auditory Corticothalamic Inputs in Normal Hearing and Noise-Induced Hearing Loss

Yanjun Zhao, Brandon Bizup and Thanos Tzounopoulos
Journal of Neuroscience 19 November 2025, 45 (47) e2394242025; https://doi.org/10.1523/JNEUROSCI.2394-24.2025
Yanjun Zhao
Pittsburgh Hearing Research Center, Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Brandon Bizup
Pittsburgh Hearing Research Center, Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Thanos Tzounopoulos
Pittsburgh Hearing Research Center, Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2394-24.2025
PubMed 
41006059
Published By 
Society for Neuroscience
History 
  • Received December 17, 2024
  • Revision received September 13, 2025
  • Accepted September 18, 2025
  • First published September 26, 2025.
  • Version of record published November 19, 2025.
Copyright & Usage 
Copyright © 2025 the authors SfN exclusive license.

Author Information

  1. Yanjun Zhao,
  2. Brandon Bizup, and
  3. Thanos Tzounopoulos
  1. Pittsburgh Hearing Research Center, Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Author contributions

  1. Author contributions: Y.Z. and T.T. designed research; Y.Z. and B.B. performed research; Y.Z. and B.B. analyzed data; Y.Z. and T.T. wrote the paper.

Disclosures

    • Received December 17, 2024.
    • Revision received September 13, 2025.
    • Accepted September 18, 2025.
  • This work was supported by National Institutes of Health grant awards R01-DC019618 and R01-DC020923 (to T.T.).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Thanos Tzounopoulos at thanos{at}pitt.edu or Yanjun Zhao at yanjunz{at}pitt.edu.

Funding

  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    DC019618; DC020923

Other Version

  • previous version (September 26, 2025).
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The Journal of Neuroscience: 45 (47)
Journal of Neuroscience
Vol. 45, Issue 47
19 Nov 2025
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Synaptic Properties of Layer 6 Auditory Corticothalamic Inputs in Normal Hearing and Noise-Induced Hearing Loss
Yanjun Zhao, Brandon Bizup, Thanos Tzounopoulos
Journal of Neuroscience 19 November 2025, 45 (47) e2394242025; DOI: 10.1523/JNEUROSCI.2394-24.2025

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Synaptic Properties of Layer 6 Auditory Corticothalamic Inputs in Normal Hearing and Noise-Induced Hearing Loss
Yanjun Zhao, Brandon Bizup, Thanos Tzounopoulos
Journal of Neuroscience 19 November 2025, 45 (47) e2394242025; DOI: 10.1523/JNEUROSCI.2394-24.2025
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Keywords

  • auditory cortex
  • electrophysiology
  • hearing loss
  • neocortex
  • neuronal excitability
  • synaptic plasticity

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