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Research Articles, Development/Plasticity/Repair

Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone–Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina

Koki Kobayashi, Taro Chaya, Hung-Ya Tu, Yamato Maeda, Yuki Nakashima, Ryotaro Tsutsumi, Haruka Yamamoto, Toshinori Tsujii, Daisuke Okuzaki and Takahisa Furukawa
Journal of Neuroscience 26 November 2025, 45 (48) e2245242025; https://doi.org/10.1523/JNEUROSCI.2245-24.2025
Koki Kobayashi
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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  • ORCID record for Koki Kobayashi
Taro Chaya
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Hung-Ya Tu
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Yamato Maeda
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Yuki Nakashima
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Ryotaro Tsutsumi
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Haruka Yamamoto
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Toshinori Tsujii
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Daisuke Okuzaki
2Genome Information Research Center, Research Institute for Microbial Diseases, The University of Osaka, Osaka 565-0871, Japan
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Takahisa Furukawa
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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  • ORCID record for Takahisa Furukawa
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2245-24.2025
PubMed 
41107067
Published By 
Society for Neuroscience
History 
  • Received November 26, 2024
  • Revision received October 3, 2025
  • Accepted October 13, 2025
  • First published October 17, 2025.
  • Version of record published November 26, 2025.
Copyright & Usage 
Copyright © 2025 the authors SfN exclusive license.

Author Information

  1. Koki Kobayashi1,
  2. Taro Chaya1,
  3. Hung-Ya Tu1,
  4. Yamato Maeda1,
  5. Yuki Nakashima1,
  6. Ryotaro Tsutsumi1,
  7. Haruka Yamamoto1,
  8. Toshinori Tsujii1,
  9. Daisuke Okuzaki2, and
  10. Takahisa Furukawa1
  1. 1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
  2. 2Genome Information Research Center, Research Institute for Microbial Diseases, The University of Osaka, Osaka 565-0871, Japan
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Author contributions

  1. Author contributions: T.C. and T.F. designed research; K.K., T.C., H-Y.T., Y.M., Y.N., R.T., H.Y., T.T., and D.O. performed research; K.K. analyzed data; K.K., T.C., and T.F. wrote the paper.

Disclosures

    • Received November 26, 2024.
    • Revision received October 3, 2025.
    • Accepted October 13, 2025.
  • We thank U. Nakagawa for LC-MS/MS analysis; M. Kadowaki, M. Wakabayashi, Y Kinooka, N. Nakashima, and T. Kaneko for technical assistance; and Editage for English language editing. This work was supported by Grant-in-Aid for Scientific Research (21H02657, 24K09996) and Grant-in-Aid for Challenging Research (Exploratory; 23K18199) from the Japan Society for the Promotion of Science, AMED-CREST (21gm1510006) from the Japan Agency for Medical Research and Development, Japan Science and Technology Agency (JST) Moonshot R&D (JPMJMS2024), JST COI-NEXT (JPMJPF2018), OU Master Plan Implementation Project, and the Takeda Science Foundation.

  • The authors declare no competing financial interests.

  • This paper contains supplemental material available at: https://doi.org/10.1523/JNEUROSCI.2245-24.2025

  • Correspondence should be addressed to Takahisa Furukawa at takahisa.furukawa{at}protein.osaka-u.ac.jp.

Funding

  • MEXT | Japan Society for the Promotion of Science (JSPS)

    21H02657; 24K09996
  • Japan Society for the Promotion of Science London (JSPS)

    23K18199
  • Japan Agency for Medical Research and Development (AMED)

    21gm1510006
  • MEXT | Japan Science and Technology Agency (JST)

    JPMJMS2024; JPMJPF2018
  • Osaka University (OU)

  • Takeda Science Foundation (TSF)

Other Version

  • previous version (October 17, 2025).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 45 (48)
Journal of Neuroscience
Vol. 45, Issue 48
26 Nov 2025
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Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone–Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina
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Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone–Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina
Koki Kobayashi, Taro Chaya, Hung-Ya Tu, Yamato Maeda, Yuki Nakashima, Ryotaro Tsutsumi, Haruka Yamamoto, Toshinori Tsujii, Daisuke Okuzaki, Takahisa Furukawa
Journal of Neuroscience 26 November 2025, 45 (48) e2245242025; DOI: 10.1523/JNEUROSCI.2245-24.2025

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Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone–Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina
Koki Kobayashi, Taro Chaya, Hung-Ya Tu, Yamato Maeda, Yuki Nakashima, Ryotaro Tsutsumi, Haruka Yamamoto, Toshinori Tsujii, Daisuke Okuzaki, Takahisa Furukawa
Journal of Neuroscience 26 November 2025, 45 (48) e2245242025; DOI: 10.1523/JNEUROSCI.2245-24.2025
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