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Research Articles, Development/Plasticity/Repair

Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone–Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina

Koki Kobayashi, Taro Chaya, Hung-Ya Tu, Yamato Maeda, Yuki Nakashima, Ryotaro Tsutsumi, Haruka Yamamoto, Toshinori Tsujii, Daisuke Okuzaki and Takahisa Furukawa
Journal of Neuroscience 26 November 2025, 45 (48) e2245242025; https://doi.org/10.1523/JNEUROSCI.2245-24.2025
Koki Kobayashi
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Taro Chaya
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Hung-Ya Tu
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Yamato Maeda
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Yuki Nakashima
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Ryotaro Tsutsumi
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Haruka Yamamoto
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Toshinori Tsujii
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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Daisuke Okuzaki
2Genome Information Research Center, Research Institute for Microbial Diseases, The University of Osaka, Osaka 565-0871, Japan
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Takahisa Furukawa
1Laboratory for Molecular and Developmental Biology, Institute for Protein Research, The University of Osaka, Osaka 565-0871, Japan
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  • ORCID record for Takahisa Furukawa
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The Journal of Neuroscience: 45 (48)
Journal of Neuroscience
Vol. 45, Issue 48
26 Nov 2025
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Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone–Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina
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Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone–Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina
Koki Kobayashi, Taro Chaya, Hung-Ya Tu, Yamato Maeda, Yuki Nakashima, Ryotaro Tsutsumi, Haruka Yamamoto, Toshinori Tsujii, Daisuke Okuzaki, Takahisa Furukawa
Journal of Neuroscience 26 November 2025, 45 (48) e2245242025; DOI: 10.1523/JNEUROSCI.2245-24.2025

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Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone–Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina
Koki Kobayashi, Taro Chaya, Hung-Ya Tu, Yamato Maeda, Yuki Nakashima, Ryotaro Tsutsumi, Haruka Yamamoto, Toshinori Tsujii, Daisuke Okuzaki, Takahisa Furukawa
Journal of Neuroscience 26 November 2025, 45 (48) e2245242025; DOI: 10.1523/JNEUROSCI.2245-24.2025
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