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Articles

Tight junctions of brain endothelium in vitro are enhanced by astroglia

JH Tao-Cheng, Z Nagy and MW Brightman
Journal of Neuroscience 1 October 1987, 7 (10) 3293-3299; https://doi.org/10.1523/JNEUROSCI.07-10-03293.1987
JH Tao-Cheng
Laboratory of Neurobiology, NIH/NINCDS, Bethesda, Maryland 20892.
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Z Nagy
Laboratory of Neurobiology, NIH/NINCDS, Bethesda, Maryland 20892.
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MW Brightman
Laboratory of Neurobiology, NIH/NINCDS, Bethesda, Maryland 20892.
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Abstract

The belts of endothelial tight junctions, which impede diffusion between blood and brain, were reduced to fragmentary, small junctions in subcultured brain endothelium. When cocultured with the capillaries' nearest neighbor, the astrocytes, these endothelial tight junctions were enhanced in length, width, and complexity, as seen by en face views of the cell membranes with freeze-fracture electron microscopy. Gap junctions, common in brain endothelium in vitro but absent in mature brain capillaries in vivo, were markedly diminished in area from among the enhanced tight junctions of the cocultures. Thus, astrocytes in vitro play a role in the formation, extent, and configuration of the junctional complexes in brain endothelium, whose diffusion barrier may likewise be influenced by astrocytes in vivo.

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The Journal of Neuroscience: 7 (10)
Journal of Neuroscience
Vol. 7, Issue 10
1 Oct 1987
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Tight junctions of brain endothelium in vitro are enhanced by astroglia
JH Tao-Cheng, Z Nagy, MW Brightman
Journal of Neuroscience 1 October 1987, 7 (10) 3293-3299; DOI: 10.1523/JNEUROSCI.07-10-03293.1987

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Tight junctions of brain endothelium in vitro are enhanced by astroglia
JH Tao-Cheng, Z Nagy, MW Brightman
Journal of Neuroscience 1 October 1987, 7 (10) 3293-3299; DOI: 10.1523/JNEUROSCI.07-10-03293.1987
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