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Articles

A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons

NL Harrison, S Vicini and JL Barker
Journal of Neuroscience 1 February 1987, 7 (2) 604-609; DOI: https://doi.org/10.1523/JNEUROSCI.07-02-00604.1987
NL Harrison
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S Vicini
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JL Barker
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Abstract

Whole-cell patch-clamp recordings were made from cultured rat hippocampal neurons to examine the effects of the steroidal general anesthetic alphaxalone (3 alpha-hydroxy 5 alpha-pregnane 11,20-dione) on responses to pharmacologically applied and physiologically released GABA. At low micromolar concentrations in the anesthetic range, alphaxalone potentiated Cl- conductance responses elicited by GABA and also prolonged evoked GABA-mediated postsynaptic potentials. Under voltage clamp at -40 mV, rapid outwardly directed synaptic currents were evoked that decayed with single exponential kinetics; mean decay time constant was 24 msec at room temperature. Alphaxalone prolonged the decay of these inhibitory postsynaptic currents by 5- to 8-fold, with no increase in peak amplitude or change in growth time. This substantial prolongation of GABA-mediated inhibitory synaptic conductance at clinically effective concentrations may contribute significantly to the anesthetic activity of alphaxalone.

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The Journal of Neuroscience: 7 (2)
Journal of Neuroscience
Vol. 7, Issue 2
1 Feb 1987
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A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons
NL Harrison, S Vicini, JL Barker
Journal of Neuroscience 1 February 1987, 7 (2) 604-609; DOI: 10.1523/JNEUROSCI.07-02-00604.1987

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A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons
NL Harrison, S Vicini, JL Barker
Journal of Neuroscience 1 February 1987, 7 (2) 604-609; DOI: 10.1523/JNEUROSCI.07-02-00604.1987
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